Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB

We previously reported that BIX-01294 (BIX), a small molecular inhibitor of euchromatic histone-lysine N-methyltransferase 2 (EHMT2/G9a), induces reactive oxygen species (ROS)-dependent autophagy in MCF-7 cells. Herein, we analyzed the epigenetic mechanism that regulates the transcription of Beclin-...

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Detalles Bibliográficos
Autores principales: Park, Sang Eun, Yi, Hye Jin, Suh, Nayoung, Park, Yun-Yong, Koh, Jae-Young, Jeong, Seong-Yun, Cho, Dong-Hyung, Kim, Choung-Soo, Hwang, Jung Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129971/
https://www.ncbi.nlm.nih.gov/pubmed/27174920
http://dx.doi.org/10.18632/oncotarget.9290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129971/
https://www.ncbi.nlm.nih.gov/pubmed/27174920
http://dx.doi.org/10.18632/oncotarget.9290

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