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Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB

We previously reported that BIX-01294 (BIX), a small molecular inhibitor of euchromatic histone-lysine N-methyltransferase 2 (EHMT2/G9a), induces reactive oxygen species (ROS)-dependent autophagy in MCF-7 cells. Herein, we analyzed the epigenetic mechanism that regulates the transcription of Beclin-...

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Detalles Bibliográficos
Autores principales:	Park, Sang Eun, Yi, Hye Jin, Suh, Nayoung, Park, Yun-Yong, Koh, Jae-Young, Jeong, Seong-Yun, Cho, Dong-Hyung, Kim, Choung-Soo, Hwang, Jung Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129971/ https://www.ncbi.nlm.nih.gov/pubmed/27174920 http://dx.doi.org/10.18632/oncotarget.9290

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