Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230

Fibroblast growth factor (FGF) ligand-dependent signaling has a fundamental role in cancer development and tumor maintenance. GSK3052230 (also known as FP-1039) is a soluble decoy receptor that sequesters FGFs and inhibits FGFR signaling. Herein, the efficacy of this molecule was tested in models of...

Descripción completa

Detalles Bibliográficos
Autores principales: Blackwell, Christina, Sherk, Christian, Fricko, Maggie, Ganji, Gopinath, Barnette, Mary, Hoang, Bao, Tunstead, James, Skedzielewski, Tina, Alsaid, Hasan, Jucker, Beat M., Minthorn, Elisabeth, Kumar, Rakesh, DeYoung, M. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129976/
https://www.ncbi.nlm.nih.gov/pubmed/27223434
http://dx.doi.org/10.18632/oncotarget.9515

Ejemplares similares

Ejemplares similares