Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer

JAK1 frameshift mutations may promote cancer cell immune evasion by impeding upregulation of the antigen presentation pathway in microsatellite unstable endometrial cancers (ECs). This study investigated the JAK1 mutation frequency, its functional implication in immune evasion and its prognostic sig...

Descripción completa

Detalles Bibliográficos
Autores principales: Stelloo, Ellen, Versluis, Marco A., Nijman, Hans W., de Bruyn, Marco, Plat, Annechien, Osse, Elisabeth M., van Dijk, Reinhardt H., Nout, Remi A., Creutzberg, Carien L., de Bock, Geertruida H., Smit, Vincent T., Bosse, Tjalling, Hollema, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129978/
https://www.ncbi.nlm.nih.gov/pubmed/27213585
http://dx.doi.org/10.18632/oncotarget.9414

Ejemplares similares

Ejemplares similares