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Recent advances in understanding & managing male infertility

Male infertility remains a struggle to definitively diagnose and treat with many men labelled as “idiopathic infertility” and eventually requiring assisted reproductive techniques.  Along those lines, research groups are continuing to explore current social and environmental factors, including the o...

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Detalles Bibliográficos
Autores principales: Bieniek, Jared M., Lo, Kirk C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130065/
https://www.ncbi.nlm.nih.gov/pubmed/27990271
http://dx.doi.org/10.12688/f1000research.9375.1
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author Bieniek, Jared M.
Lo, Kirk C.
author_facet Bieniek, Jared M.
Lo, Kirk C.
author_sort Bieniek, Jared M.
collection PubMed
description Male infertility remains a struggle to definitively diagnose and treat with many men labelled as “idiopathic infertility” and eventually requiring assisted reproductive techniques.  Along those lines, research groups are continuing to explore current social and environmental factors, including the obesity epidemic, and their effects on male fertility potential.  Novel biomarkers of natural fertility status and azoospermia etiology have additionally seen recent attention with ACRV1 and TEX101/ECM1 assays either currently or soon to be commercially available.  Despite these advancements, however, medical treatment options have seen little progress.  Though surgical therapies have similarly seen little transformation, groups are exploring the use of testicular sperm for couples with elevated sperm DNA fragmentation and either planned or previously failed IVF/ICSI.  Concerted collaborative efforts will be needed as we move forward to better understand the challenges men face when struggling to conceive.
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spelling pubmed-51300652016-12-16 Recent advances in understanding & managing male infertility Bieniek, Jared M. Lo, Kirk C. F1000Res Review Male infertility remains a struggle to definitively diagnose and treat with many men labelled as “idiopathic infertility” and eventually requiring assisted reproductive techniques.  Along those lines, research groups are continuing to explore current social and environmental factors, including the obesity epidemic, and their effects on male fertility potential.  Novel biomarkers of natural fertility status and azoospermia etiology have additionally seen recent attention with ACRV1 and TEX101/ECM1 assays either currently or soon to be commercially available.  Despite these advancements, however, medical treatment options have seen little progress.  Though surgical therapies have similarly seen little transformation, groups are exploring the use of testicular sperm for couples with elevated sperm DNA fragmentation and either planned or previously failed IVF/ICSI.  Concerted collaborative efforts will be needed as we move forward to better understand the challenges men face when struggling to conceive. F1000Research 2016-11-24 /pmc/articles/PMC5130065/ /pubmed/27990271 http://dx.doi.org/10.12688/f1000research.9375.1 Text en Copyright: © 2016 Bieniek JM and Lo KC http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Bieniek, Jared M.
Lo, Kirk C.
Recent advances in understanding & managing male infertility
title Recent advances in understanding & managing male infertility
title_full Recent advances in understanding & managing male infertility
title_fullStr Recent advances in understanding & managing male infertility
title_full_unstemmed Recent advances in understanding & managing male infertility
title_short Recent advances in understanding & managing male infertility
title_sort recent advances in understanding & managing male infertility
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130065/
https://www.ncbi.nlm.nih.gov/pubmed/27990271
http://dx.doi.org/10.12688/f1000research.9375.1
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