A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity

Hirschsprung disease (HSCR) is characterized by absence of enteric neurons from the distal colon and severe intestinal dysmotility. To understand the pathophysiology and genetics of HSCR we developed a unique zebrafish model that allows combined genetic, developmental and in vivo physiological studi...

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Detalles Bibliográficos
Autores principales: Heanue, Tiffany A., Boesmans, Werend, Bell, Donald M., Kawakami, Koichi, Vanden Berghe, Pieter, Pachnis, Vassilis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130169/
https://www.ncbi.nlm.nih.gov/pubmed/27902697
http://dx.doi.org/10.1371/journal.pgen.1006439

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