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Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems

The mammalian main olfactory system contains several subsystems that differ not only in the receptors they express and the glomerular targets they innervate within the main olfactory bulb (MOB), but also in the strategies they use to process odor information. The canonical main olfactory system empl...

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Autores principales: Uytingco, Cedric R., Puche, Adam C., Munger, Steven D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130179/
https://www.ncbi.nlm.nih.gov/pubmed/27902696
http://dx.doi.org/10.1371/journal.pone.0165343
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author Uytingco, Cedric R.
Puche, Adam C.
Munger, Steven D.
author_facet Uytingco, Cedric R.
Puche, Adam C.
Munger, Steven D.
author_sort Uytingco, Cedric R.
collection PubMed
description The mammalian main olfactory system contains several subsystems that differ not only in the receptors they express and the glomerular targets they innervate within the main olfactory bulb (MOB), but also in the strategies they use to process odor information. The canonical main olfactory system employs a combinatorial coding strategy that represents odorant identity as a pattern of glomerular activity. By contrast, the "GC-D/necklace" olfactory subsystem—formed by olfactory sensory neurons expressing the receptor guanylyl cyclase GC-D and their target necklace glomeruli (NGs) encircling the caudal MOB—is critical for the detection of a small number of semiochemicals that promote the acquisition of food preferences. The formation of these socially-transmitted food preferences requires the animal to integrate information about two types of olfactory stimuli: these specialized social chemosignals and the food odors themselves. However, the neural mechanisms with which the GC-D/necklace subsystem processes this information are unclear. We used stimulus-induced increases in intrinsic fluorescence signals to map functional circuitry associated with NGs and canonical glomeruli (CGs) in the MOB. As expected, CG-associated activity spread laterally through both the glomerular and external plexiform layers associated with activated glomeruli. Activation of CGs or NGs resulted in activity spread between the two types of glomeruli; there was no evidence of preferential connectivity between individual necklace glomeruli. These results support previous anatomical findings that suggest the canonical and GC-D/necklace subsystems are functionally connected and may integrate general odor and semiochemical information in the MOB.
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spelling pubmed-51301792016-12-15 Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems Uytingco, Cedric R. Puche, Adam C. Munger, Steven D. PLoS One Research Article The mammalian main olfactory system contains several subsystems that differ not only in the receptors they express and the glomerular targets they innervate within the main olfactory bulb (MOB), but also in the strategies they use to process odor information. The canonical main olfactory system employs a combinatorial coding strategy that represents odorant identity as a pattern of glomerular activity. By contrast, the "GC-D/necklace" olfactory subsystem—formed by olfactory sensory neurons expressing the receptor guanylyl cyclase GC-D and their target necklace glomeruli (NGs) encircling the caudal MOB—is critical for the detection of a small number of semiochemicals that promote the acquisition of food preferences. The formation of these socially-transmitted food preferences requires the animal to integrate information about two types of olfactory stimuli: these specialized social chemosignals and the food odors themselves. However, the neural mechanisms with which the GC-D/necklace subsystem processes this information are unclear. We used stimulus-induced increases in intrinsic fluorescence signals to map functional circuitry associated with NGs and canonical glomeruli (CGs) in the MOB. As expected, CG-associated activity spread laterally through both the glomerular and external plexiform layers associated with activated glomeruli. Activation of CGs or NGs resulted in activity spread between the two types of glomeruli; there was no evidence of preferential connectivity between individual necklace glomeruli. These results support previous anatomical findings that suggest the canonical and GC-D/necklace subsystems are functionally connected and may integrate general odor and semiochemical information in the MOB. Public Library of Science 2016-11-30 /pmc/articles/PMC5130179/ /pubmed/27902696 http://dx.doi.org/10.1371/journal.pone.0165343 Text en © 2016 Uytingco et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Uytingco, Cedric R.
Puche, Adam C.
Munger, Steven D.
Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems
title Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems
title_full Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems
title_fullStr Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems
title_full_unstemmed Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems
title_short Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems
title_sort interglomerular connectivity within the canonical and gc-d/necklace olfactory subsystems
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130179/
https://www.ncbi.nlm.nih.gov/pubmed/27902696
http://dx.doi.org/10.1371/journal.pone.0165343
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