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Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases

Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the active state, the catalytic core oscillates between open, intermediate, and closed conformations. Currently, the intramolecular interactions th...

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Detalles Bibliográficos
Autores principales:	Meharena, Hiruy S., Fan, Xiaorui, Ahuja, Lalima G., Keshwani, Malik M., McClendon, Christopher L., Chen, Angela M., Adams, Joseph A., Taylor, Susan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130182/ https://www.ncbi.nlm.nih.gov/pubmed/27902690 http://dx.doi.org/10.1371/journal.pbio.2000127

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