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EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation
Theta burst stimulation (TBS) is thought to affect reward processing mechanisms, which may increase and decrease reward sensitivity. To test the ability of TBS to modulate response to strong primary rewards, participants hypersensitive to primary rewards were recruited. Twenty men and women with at...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130195/ https://www.ncbi.nlm.nih.gov/pubmed/27902711 http://dx.doi.org/10.1371/journal.pone.0165646 |
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author | Prause, Nicole Siegle, Greg J. Deblieck, Choi Wu, Allan Iacoboni, Marco |
author_facet | Prause, Nicole Siegle, Greg J. Deblieck, Choi Wu, Allan Iacoboni, Marco |
author_sort | Prause, Nicole |
collection | PubMed |
description | Theta burst stimulation (TBS) is thought to affect reward processing mechanisms, which may increase and decrease reward sensitivity. To test the ability of TBS to modulate response to strong primary rewards, participants hypersensitive to primary rewards were recruited. Twenty men and women with at least two opposite-sex, sexual partners in the last year received two forms of TBS. Stimulations were randomized to avoid order effects and separated by 2 hours to reduce carryover. The two TBS forms have been demonstrated to inhibit (continuous) or excite (intermittent) the left dorsolateral prefrontal cortex using different pulse patterns, which links to brain areas associated with reward conditioning. After each TBS, participants completed tasks assessing their reward responsiveness to monetary and sexual rewards. Electroencephalography (EEG) was recorded. They also reported their number of orgasms in the weekend following stimulation. This signal was malleable by TBS, where excitatory TBS resulted in lower EEG alpha relative to inhibitory TBS to primary rewards. EEG responses to sexual rewards in the lab (following both forms of TBS) predicted the number of orgasms experienced over the forthcoming weekend. TBS may be useful in modifying hypersensitivity or hyposensitivity to primary rewards that predict sexual behaviors. Since TBS altered the anticipation of a sexual reward, TBS may offer a novel treatment for sexual desire problems. |
format | Online Article Text |
id | pubmed-5130195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-51301952016-12-15 EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation Prause, Nicole Siegle, Greg J. Deblieck, Choi Wu, Allan Iacoboni, Marco PLoS One Research Article Theta burst stimulation (TBS) is thought to affect reward processing mechanisms, which may increase and decrease reward sensitivity. To test the ability of TBS to modulate response to strong primary rewards, participants hypersensitive to primary rewards were recruited. Twenty men and women with at least two opposite-sex, sexual partners in the last year received two forms of TBS. Stimulations were randomized to avoid order effects and separated by 2 hours to reduce carryover. The two TBS forms have been demonstrated to inhibit (continuous) or excite (intermittent) the left dorsolateral prefrontal cortex using different pulse patterns, which links to brain areas associated with reward conditioning. After each TBS, participants completed tasks assessing their reward responsiveness to monetary and sexual rewards. Electroencephalography (EEG) was recorded. They also reported their number of orgasms in the weekend following stimulation. This signal was malleable by TBS, where excitatory TBS resulted in lower EEG alpha relative to inhibitory TBS to primary rewards. EEG responses to sexual rewards in the lab (following both forms of TBS) predicted the number of orgasms experienced over the forthcoming weekend. TBS may be useful in modifying hypersensitivity or hyposensitivity to primary rewards that predict sexual behaviors. Since TBS altered the anticipation of a sexual reward, TBS may offer a novel treatment for sexual desire problems. Public Library of Science 2016-11-30 /pmc/articles/PMC5130195/ /pubmed/27902711 http://dx.doi.org/10.1371/journal.pone.0165646 Text en © 2016 Prause et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Prause, Nicole Siegle, Greg J. Deblieck, Choi Wu, Allan Iacoboni, Marco EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation |
title | EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation |
title_full | EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation |
title_fullStr | EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation |
title_full_unstemmed | EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation |
title_short | EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation |
title_sort | eeg to primary rewards: predictive utility and malleability by brain stimulation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130195/ https://www.ncbi.nlm.nih.gov/pubmed/27902711 http://dx.doi.org/10.1371/journal.pone.0165646 |
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