Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium

Canonical Wnt signaling is known to promote proliferation of olfactory stem cells. In order to investigate the effects of a constitutive activation of Wnt signaling in Sox2-positive precursor cells of the olfactory epithelium, we used transgenic mice that allowed an inducible deletion of exon 3 of t...

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Detalles Bibliográficos
Autores principales: Engel, Nils W., Neumann, Julia E., Ahlfeld, Julia, Wefers, Annika K., Merk, Daniel J., Ohli, Jasmin, Schüller, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130221/
https://www.ncbi.nlm.nih.gov/pubmed/27902722
http://dx.doi.org/10.1371/journal.pone.0166690

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