Cargando…

Physical Properties of Blood Are Altered in Young and Lean Women with Polycystic Ovary Syndrome

Classic features of polycystic ovary syndrome (PCOS) include derangement of metabolic and cardiovascular health, and vascular dysfunction is commonly reported. These comorbidities indicate impaired blood flow; however, other than limited reports of increased plasma viscosity, surprisingly little is...

Descripción completa

Detalles Bibliográficos
Autores principales: Simmonds, Michael J., Milne, Nikki, Ong, Kee, Brotherton, Emily, McNamee, Antony P., Horobin, Jarod, Sabapathy, Surendran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130252/
https://www.ncbi.nlm.nih.gov/pubmed/27902766
http://dx.doi.org/10.1371/journal.pone.0167290
_version_ 1782470702307213312
author Simmonds, Michael J.
Milne, Nikki
Ong, Kee
Brotherton, Emily
McNamee, Antony P.
Horobin, Jarod
Sabapathy, Surendran
author_facet Simmonds, Michael J.
Milne, Nikki
Ong, Kee
Brotherton, Emily
McNamee, Antony P.
Horobin, Jarod
Sabapathy, Surendran
author_sort Simmonds, Michael J.
collection PubMed
description Classic features of polycystic ovary syndrome (PCOS) include derangement of metabolic and cardiovascular health, and vascular dysfunction is commonly reported. These comorbidities indicate impaired blood flow; however, other than limited reports of increased plasma viscosity, surprisingly little is known regarding the physical properties of blood in PCOS. We aimed to investigate whether haemorheology was impaired in women with PCOS. We thus measured a comprehensive haemorheological profile, in a case-control design, of lean women with PCOS and age-matched healthy controls. A clinical examination determined similar cardiovascular risk for the two groups. Whole blood and plasma viscosity was measured using a cone-plate viscometer. The magnitude and rate of red blood cell (RBC) aggregation was determined using a light-transmission aggregometer, and the degree of RBC deformability was measured via laser-diffraction ektacytometry. Plasma viscosity was significantly increased in women with PCOS. Blood viscosity was also increased for PCOS at lower-to-moderate shear rates in both native and standardised haematocrit samples. The magnitude of RBC aggregation–a primary determinant of low-shear blood viscosity–was significantly increased in PCOS at native and 0.4 L·L(-1) haematocrit. No difference was detected between PCOS and CON groups for RBC deformability measurements. A novel measure indicating the effectiveness of oxygen transport by RBC (i.e., the haematocrit-to-viscosity ratio; HVR) was decreased at all shear rates in women with PCOS. In a group of young and lean women with PCOS with an unremarkable cardiovascular risk profile based on clinical data, significant haemorheological impairment was observed. The degree of haemorheological derangement observed in the present study reflects that of overt chronic disease, and provides an avenue for future therapeutic intervention in PCOS.
format Online
Article
Text
id pubmed-5130252
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-51302522016-12-15 Physical Properties of Blood Are Altered in Young and Lean Women with Polycystic Ovary Syndrome Simmonds, Michael J. Milne, Nikki Ong, Kee Brotherton, Emily McNamee, Antony P. Horobin, Jarod Sabapathy, Surendran PLoS One Research Article Classic features of polycystic ovary syndrome (PCOS) include derangement of metabolic and cardiovascular health, and vascular dysfunction is commonly reported. These comorbidities indicate impaired blood flow; however, other than limited reports of increased plasma viscosity, surprisingly little is known regarding the physical properties of blood in PCOS. We aimed to investigate whether haemorheology was impaired in women with PCOS. We thus measured a comprehensive haemorheological profile, in a case-control design, of lean women with PCOS and age-matched healthy controls. A clinical examination determined similar cardiovascular risk for the two groups. Whole blood and plasma viscosity was measured using a cone-plate viscometer. The magnitude and rate of red blood cell (RBC) aggregation was determined using a light-transmission aggregometer, and the degree of RBC deformability was measured via laser-diffraction ektacytometry. Plasma viscosity was significantly increased in women with PCOS. Blood viscosity was also increased for PCOS at lower-to-moderate shear rates in both native and standardised haematocrit samples. The magnitude of RBC aggregation–a primary determinant of low-shear blood viscosity–was significantly increased in PCOS at native and 0.4 L·L(-1) haematocrit. No difference was detected between PCOS and CON groups for RBC deformability measurements. A novel measure indicating the effectiveness of oxygen transport by RBC (i.e., the haematocrit-to-viscosity ratio; HVR) was decreased at all shear rates in women with PCOS. In a group of young and lean women with PCOS with an unremarkable cardiovascular risk profile based on clinical data, significant haemorheological impairment was observed. The degree of haemorheological derangement observed in the present study reflects that of overt chronic disease, and provides an avenue for future therapeutic intervention in PCOS. Public Library of Science 2016-11-30 /pmc/articles/PMC5130252/ /pubmed/27902766 http://dx.doi.org/10.1371/journal.pone.0167290 Text en © 2016 Simmonds et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Simmonds, Michael J.
Milne, Nikki
Ong, Kee
Brotherton, Emily
McNamee, Antony P.
Horobin, Jarod
Sabapathy, Surendran
Physical Properties of Blood Are Altered in Young and Lean Women with Polycystic Ovary Syndrome
title Physical Properties of Blood Are Altered in Young and Lean Women with Polycystic Ovary Syndrome
title_full Physical Properties of Blood Are Altered in Young and Lean Women with Polycystic Ovary Syndrome
title_fullStr Physical Properties of Blood Are Altered in Young and Lean Women with Polycystic Ovary Syndrome
title_full_unstemmed Physical Properties of Blood Are Altered in Young and Lean Women with Polycystic Ovary Syndrome
title_short Physical Properties of Blood Are Altered in Young and Lean Women with Polycystic Ovary Syndrome
title_sort physical properties of blood are altered in young and lean women with polycystic ovary syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130252/
https://www.ncbi.nlm.nih.gov/pubmed/27902766
http://dx.doi.org/10.1371/journal.pone.0167290
work_keys_str_mv AT simmondsmichaelj physicalpropertiesofbloodarealteredinyoungandleanwomenwithpolycysticovarysyndrome
AT milnenikki physicalpropertiesofbloodarealteredinyoungandleanwomenwithpolycysticovarysyndrome
AT ongkee physicalpropertiesofbloodarealteredinyoungandleanwomenwithpolycysticovarysyndrome
AT brothertonemily physicalpropertiesofbloodarealteredinyoungandleanwomenwithpolycysticovarysyndrome
AT mcnameeantonyp physicalpropertiesofbloodarealteredinyoungandleanwomenwithpolycysticovarysyndrome
AT horobinjarod physicalpropertiesofbloodarealteredinyoungandleanwomenwithpolycysticovarysyndrome
AT sabapathysurendran physicalpropertiesofbloodarealteredinyoungandleanwomenwithpolycysticovarysyndrome