Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

Proper function of lysosomes is particularly important in neurons, as they cannot dilute accumulated toxic molecules and aggregates by cell division. Thus, impairment of lysosomal function plays an important role in neuronal degeneration and in the pathogenesis of numerous neurodegenerative diseases...

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Detalles Bibliográficos
Autores principales: Cermak, Stjepko, Kosicek, Marko, Mladenovic-Djordjevic, Aleksandra, Smiljanic, Kosara, Kanazir, Selma, Hecimovic, Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130271/
https://www.ncbi.nlm.nih.gov/pubmed/27902765
http://dx.doi.org/10.1371/journal.pone.0167428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130271/
https://www.ncbi.nlm.nih.gov/pubmed/27902765
http://dx.doi.org/10.1371/journal.pone.0167428

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