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Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells

Efforts to control mammalian gene expression with ligand-responsive riboswitches have been hindered by lack of a general method for generating efficient switches in mammalian systems. Here we describe a rational-design approach that enables rapid development of efficient cis-acting aptazyme riboswit...

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Detalles Bibliográficos
Autores principales: Zhong, Guocai, Wang, Haimin, Bailey, Charles C, Gao, Guangping, Farzan, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130294/
https://www.ncbi.nlm.nih.gov/pubmed/27805569
http://dx.doi.org/10.7554/eLife.18858

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