Cargando…

Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface

The mechanism by which the HIV-1 MPER epitope is recognized by the potent neutralizing antibody 10E8 at membrane interfaces remains poorly understood. To solve this problem, we have optimized a 10E8 peptide epitope and analyzed the structure and binding activities of the antibody in membrane and mem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rujas, Edurne, Caaveiro, Jose M. M., Partida-Hanon, Angélica, Gulzar, Naveed, Morante, Koldo, Apellániz, Beatriz, García-Porras, Miguel, Bruix, Marta, Tsumoto, Kouhei, Scott, Jamie K., Jiménez, M. Ángeles, Nieva, José L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131266/ https://www.ncbi.nlm.nih.gov/pubmed/27905530 http://dx.doi.org/10.1038/srep38177

Ejemplares similares

Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10
por: Rujas, Edurne, et al.
Publicado: (2015)

Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope
por: Torralba, Johana, et al.
Publicado: (2022)

Structural basis for self-assembly of a cytolytic pore lined by protein and lipid
por: Tanaka, Koji, et al.
Publicado: (2015)

The Isolation of New Pore-Forming Toxins from the Sea Anemone Actinia fragacea Provides Insights into the Mechanisms of Actinoporin Evolution
por: Morante, Koldo, et al.
Publicado: (2019)

Structure and role of the linker domain of the iron surface-determinant protein IsdH in heme transportation in Staphylococcus aureus
por: Valenciano-Bellido, Sandra, et al.
Publicado: (2022)

Functional Delineation of a Protein–Membrane Interaction Hotspot Site on the HIV-1 Neutralizing Antibody 10E8
por: Insausti, Sara, et al.
Publicado: (2022)

Identification of a Membrane-bound Prepore Species Clarifies the Lytic Mechanism of Actinoporins
por: Morante, Koldo, et al.
Publicado: (2016)

Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions
por: Carravilla, Pablo, et al.
Publicado: (2019)

Crystal structure of the capsular polysaccharide synthesizing protein CapE of Staphylococcus aureus
por: Miyafusa, Takamitsu, et al.
Publicado: (2013)

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column
por: Kiyoshi, Masato, et al.
Publicado: (2018)

Discovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus
por: Nakano, Koichiro, et al.
Publicado: (2015)

Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3
por: Kinoshita, Seisho, et al.
Publicado: (2022)

Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile
por: Rujas, Edurne, et al.
Publicado: (2021)

Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin
por: Kudo, Shota, et al.
Publicado: (2017)

Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody
por: Akiba, Hiroki, et al.
Publicado: (2019)

Modulation of a conformational ensemble by a small molecule that inhibits key protein–protein interactions involved in cell adhesion
por: Senoo, Akinobu, et al.
Publicado: (2023)

Targeting hemoglobin receptors IsdH and IsdB of Staphylococcus aureus with a single VHH antibody inhibits bacterial growth
por: Valenciano-Bellido, Sandra, et al.
Publicado: (2023)

Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI
por: Kiyoshi, Masato, et al.
Publicado: (2015)

Structural basis for antigen recognition by methylated lysine–specific antibodies
por: Ishii, Misaki, et al.
Publicado: (2020)

Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments
por: Rujas, Edurne, et al.
Publicado: (2020)

Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex
por: Kiyoshi, Masato, et al.
Publicado: (2014)

Mechanism of dimerization and structural features of human LI-cadherin
por: Yui, Anna, et al.
Publicado: (2021)

Anti-InlA single-domain antibodies that inhibit the cell invasion of Listeria monocytogenes
por: Yamazaki, Taichi, et al.
Publicado: (2023)

Structure of Fungal α Mating Pheromone in Membrane Mimetics Suggests a Possible Role for Regulation at the Water-Membrane Interface
por: Partida-Hanon, Angélica, et al.
Publicado: (2020)

The three lives of viral fusion peptides
por: Apellániz, Beatriz, et al.
Publicado: (2014)

Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin
por: Tashima, Takumi, et al.
Publicado: (2018)

Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1
por: Queliconi, Bruno Barros, et al.
Publicado: (2021)

Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis
por: Yokoo, Takanori, et al.
Publicado: (2022)

Epitope-Analyzer: A structure-based webtool to analyze broadly neutralizing epitopes
por: Montiel-Garcia, Daniel, et al.
Publicado: (2022)

Engineering pan–HIV-1 neutralization potency through multispecific antibody avidity
por: Rujas, Edurne, et al.
Publicado: (2022)

Epitope-targeting platform for broadly protective influenza vaccines
por: Zeigler, David F., et al.
Publicado: (2021)

Anti-EGFR antibody 528 binds to domain III of EGFR at a site shifted from the cetuximab epitope
por: Makabe, Koki, et al.
Publicado: (2021)

Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses
por: Kassardjian, Audrey, et al.
Publicado: (2023)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

Transmembrane Helices Are an Overlooked Source of Major Histocompatibility Complex Class I Epitopes
por: Bianchi, Frans, et al.
Publicado: (2017)

Sensing HIV Protease and Its Inhibitor Using “Helical Epitope”—Imprinted Polymers
por: Chou, Chien-Yu, et al.
Publicado: (2020)

Microsecond molecular dynamics suggest that a non-synonymous mutation, frequently observed in patients with mild symptoms in Tokyo, alters dynamics of the SARS-CoV-2 main protease
por: Kuroda, Daisuke, et al.
Publicado: (2021)

Addition of arginine hydrochloride and proline to the culture medium enhances recombinant protein expression in Brevibacillus choshinensis: The case of RBD of SARS-CoV-2 spike protein and its antibody
por: Matsunaga, Ryo, et al.
Publicado: (2022)

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies
por: Rujas, Edurne, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pd7pnm7kje0ibdsl6fcpnijegh