Cargando…

Microwave Heating of Synthetic Skin Samples for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated Decrystallization Technique

[Image: see text] Physical stability of synthetic skin samples during their exposure to microwave heating was investigated to demonstrate the use of the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique for potential biomedical applications. In this regard, optical microsc...

Descripción completa

Detalles Bibliográficos
Autores principales: Toker, Salih, Boone-Kukoyi, Zainab, Thompson, Nishone, Ajifa, Hillary, Clement, Travis, Ozturk, Birol, Aslan, Kadir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131323/
https://www.ncbi.nlm.nih.gov/pubmed/27917407
http://dx.doi.org/10.1021/acsomega.6b00233
_version_ 1782470872821399552
author Toker, Salih
Boone-Kukoyi, Zainab
Thompson, Nishone
Ajifa, Hillary
Clement, Travis
Ozturk, Birol
Aslan, Kadir
author_facet Toker, Salih
Boone-Kukoyi, Zainab
Thompson, Nishone
Ajifa, Hillary
Clement, Travis
Ozturk, Birol
Aslan, Kadir
author_sort Toker, Salih
collection PubMed
description [Image: see text] Physical stability of synthetic skin samples during their exposure to microwave heating was investigated to demonstrate the use of the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique for potential biomedical applications. In this regard, optical microscopy and temperature measurements were employed for the qualitative and quantitative assessment of damage to synthetic skin samples during 20 s intermittent microwave heating using a monomode microwave source (at 8 GHz, 2–20 W) up to 120 s. The extent of damage to synthetic skin samples, assessed by the change in the surface area of skin samples, was negligible for microwave power of ≤7 W and more extensive damage (>50%) to skin samples occurred when exposed to >7 W at initial temperature range of 20–39 °C. The initial temperature of synthetic skin samples significantly affected the extent of change in temperature of synthetic skin samples during their exposure to microwave heating. The proof of principle use of the MAMAD technique was demonstrated for the decrystallization of a model biological crystal (l-alanine) placed under synthetic skin samples in the presence of gold nanoparticles. Our results showed that the size (initial size ∼850 μm) of l-alanine crystals can be reduced up to 60% in 120 s without damage to synthetic skin samples using the MAMAD technique. Finite-difference time-domain-based simulations of the electric field distribution of an 8 GHz monomode microwave radiation showed that synthetic skin samples are predicted to absorb ∼92.2% of the microwave radiation.
format Online
Article
Text
id pubmed-5131323
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-51313232016-12-02 Microwave Heating of Synthetic Skin Samples for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated Decrystallization Technique Toker, Salih Boone-Kukoyi, Zainab Thompson, Nishone Ajifa, Hillary Clement, Travis Ozturk, Birol Aslan, Kadir ACS Omega [Image: see text] Physical stability of synthetic skin samples during their exposure to microwave heating was investigated to demonstrate the use of the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique for potential biomedical applications. In this regard, optical microscopy and temperature measurements were employed for the qualitative and quantitative assessment of damage to synthetic skin samples during 20 s intermittent microwave heating using a monomode microwave source (at 8 GHz, 2–20 W) up to 120 s. The extent of damage to synthetic skin samples, assessed by the change in the surface area of skin samples, was negligible for microwave power of ≤7 W and more extensive damage (>50%) to skin samples occurred when exposed to >7 W at initial temperature range of 20–39 °C. The initial temperature of synthetic skin samples significantly affected the extent of change in temperature of synthetic skin samples during their exposure to microwave heating. The proof of principle use of the MAMAD technique was demonstrated for the decrystallization of a model biological crystal (l-alanine) placed under synthetic skin samples in the presence of gold nanoparticles. Our results showed that the size (initial size ∼850 μm) of l-alanine crystals can be reduced up to 60% in 120 s without damage to synthetic skin samples using the MAMAD technique. Finite-difference time-domain-based simulations of the electric field distribution of an 8 GHz monomode microwave radiation showed that synthetic skin samples are predicted to absorb ∼92.2% of the microwave radiation. American Chemical Society 2016-11-01 /pmc/articles/PMC5131323/ /pubmed/27917407 http://dx.doi.org/10.1021/acsomega.6b00233 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Toker, Salih
Boone-Kukoyi, Zainab
Thompson, Nishone
Ajifa, Hillary
Clement, Travis
Ozturk, Birol
Aslan, Kadir
Microwave Heating of Synthetic Skin Samples for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated Decrystallization Technique
title Microwave Heating of Synthetic Skin Samples for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated Decrystallization Technique
title_full Microwave Heating of Synthetic Skin Samples for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated Decrystallization Technique
title_fullStr Microwave Heating of Synthetic Skin Samples for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated Decrystallization Technique
title_full_unstemmed Microwave Heating of Synthetic Skin Samples for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated Decrystallization Technique
title_short Microwave Heating of Synthetic Skin Samples for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated Decrystallization Technique
title_sort microwave heating of synthetic skin samples for potential treatment of gout using the metal-assisted and microwave-accelerated decrystallization technique
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131323/
https://www.ncbi.nlm.nih.gov/pubmed/27917407
http://dx.doi.org/10.1021/acsomega.6b00233
work_keys_str_mv AT tokersalih microwaveheatingofsyntheticskinsamplesforpotentialtreatmentofgoutusingthemetalassistedandmicrowaveaccelerateddecrystallizationtechnique
AT boonekukoyizainab microwaveheatingofsyntheticskinsamplesforpotentialtreatmentofgoutusingthemetalassistedandmicrowaveaccelerateddecrystallizationtechnique
AT thompsonnishone microwaveheatingofsyntheticskinsamplesforpotentialtreatmentofgoutusingthemetalassistedandmicrowaveaccelerateddecrystallizationtechnique
AT ajifahillary microwaveheatingofsyntheticskinsamplesforpotentialtreatmentofgoutusingthemetalassistedandmicrowaveaccelerateddecrystallizationtechnique
AT clementtravis microwaveheatingofsyntheticskinsamplesforpotentialtreatmentofgoutusingthemetalassistedandmicrowaveaccelerateddecrystallizationtechnique
AT ozturkbirol microwaveheatingofsyntheticskinsamplesforpotentialtreatmentofgoutusingthemetalassistedandmicrowaveaccelerateddecrystallizationtechnique
AT aslankadir microwaveheatingofsyntheticskinsamplesforpotentialtreatmentofgoutusingthemetalassistedandmicrowaveaccelerateddecrystallizationtechnique