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Microwave Heating of Synthetic Skin Samples for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated Decrystallization Technique
[Image: see text] Physical stability of synthetic skin samples during their exposure to microwave heating was investigated to demonstrate the use of the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique for potential biomedical applications. In this regard, optical microsc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131323/ https://www.ncbi.nlm.nih.gov/pubmed/27917407 http://dx.doi.org/10.1021/acsomega.6b00233 |
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author | Toker, Salih Boone-Kukoyi, Zainab Thompson, Nishone Ajifa, Hillary Clement, Travis Ozturk, Birol Aslan, Kadir |
author_facet | Toker, Salih Boone-Kukoyi, Zainab Thompson, Nishone Ajifa, Hillary Clement, Travis Ozturk, Birol Aslan, Kadir |
author_sort | Toker, Salih |
collection | PubMed |
description | [Image: see text] Physical stability of synthetic skin samples during their exposure to microwave heating was investigated to demonstrate the use of the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique for potential biomedical applications. In this regard, optical microscopy and temperature measurements were employed for the qualitative and quantitative assessment of damage to synthetic skin samples during 20 s intermittent microwave heating using a monomode microwave source (at 8 GHz, 2–20 W) up to 120 s. The extent of damage to synthetic skin samples, assessed by the change in the surface area of skin samples, was negligible for microwave power of ≤7 W and more extensive damage (>50%) to skin samples occurred when exposed to >7 W at initial temperature range of 20–39 °C. The initial temperature of synthetic skin samples significantly affected the extent of change in temperature of synthetic skin samples during their exposure to microwave heating. The proof of principle use of the MAMAD technique was demonstrated for the decrystallization of a model biological crystal (l-alanine) placed under synthetic skin samples in the presence of gold nanoparticles. Our results showed that the size (initial size ∼850 μm) of l-alanine crystals can be reduced up to 60% in 120 s without damage to synthetic skin samples using the MAMAD technique. Finite-difference time-domain-based simulations of the electric field distribution of an 8 GHz monomode microwave radiation showed that synthetic skin samples are predicted to absorb ∼92.2% of the microwave radiation. |
format | Online Article Text |
id | pubmed-5131323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-51313232016-12-02 Microwave Heating of Synthetic Skin Samples for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated Decrystallization Technique Toker, Salih Boone-Kukoyi, Zainab Thompson, Nishone Ajifa, Hillary Clement, Travis Ozturk, Birol Aslan, Kadir ACS Omega [Image: see text] Physical stability of synthetic skin samples during their exposure to microwave heating was investigated to demonstrate the use of the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique for potential biomedical applications. In this regard, optical microscopy and temperature measurements were employed for the qualitative and quantitative assessment of damage to synthetic skin samples during 20 s intermittent microwave heating using a monomode microwave source (at 8 GHz, 2–20 W) up to 120 s. The extent of damage to synthetic skin samples, assessed by the change in the surface area of skin samples, was negligible for microwave power of ≤7 W and more extensive damage (>50%) to skin samples occurred when exposed to >7 W at initial temperature range of 20–39 °C. The initial temperature of synthetic skin samples significantly affected the extent of change in temperature of synthetic skin samples during their exposure to microwave heating. The proof of principle use of the MAMAD technique was demonstrated for the decrystallization of a model biological crystal (l-alanine) placed under synthetic skin samples in the presence of gold nanoparticles. Our results showed that the size (initial size ∼850 μm) of l-alanine crystals can be reduced up to 60% in 120 s without damage to synthetic skin samples using the MAMAD technique. Finite-difference time-domain-based simulations of the electric field distribution of an 8 GHz monomode microwave radiation showed that synthetic skin samples are predicted to absorb ∼92.2% of the microwave radiation. American Chemical Society 2016-11-01 /pmc/articles/PMC5131323/ /pubmed/27917407 http://dx.doi.org/10.1021/acsomega.6b00233 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Toker, Salih Boone-Kukoyi, Zainab Thompson, Nishone Ajifa, Hillary Clement, Travis Ozturk, Birol Aslan, Kadir Microwave Heating of Synthetic Skin Samples for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated Decrystallization Technique |
title | Microwave Heating of Synthetic Skin Samples
for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated
Decrystallization Technique |
title_full | Microwave Heating of Synthetic Skin Samples
for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated
Decrystallization Technique |
title_fullStr | Microwave Heating of Synthetic Skin Samples
for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated
Decrystallization Technique |
title_full_unstemmed | Microwave Heating of Synthetic Skin Samples
for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated
Decrystallization Technique |
title_short | Microwave Heating of Synthetic Skin Samples
for Potential Treatment of Gout Using the Metal-Assisted and Microwave-Accelerated
Decrystallization Technique |
title_sort | microwave heating of synthetic skin samples
for potential treatment of gout using the metal-assisted and microwave-accelerated
decrystallization technique |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131323/ https://www.ncbi.nlm.nih.gov/pubmed/27917407 http://dx.doi.org/10.1021/acsomega.6b00233 |
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