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Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes

With the rapidly increasing demands for ultrasensitive biodetection, the design and applications of new nano-scale materials for development of sensors based on optical and electrochemical transducers have attracted substantial interest. In particular, given the comparable sizes of nanomaterials and...

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Autores principales: Rawson, F. J., Cole, M. T., Hicks, J. M., Aylott, J. W., Milne, W. I., Collins, C. M., Jackson, S. K., Silman, N. J., Mendes, P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131336/
https://www.ncbi.nlm.nih.gov/pubmed/27905472
http://dx.doi.org/10.1038/srep37672
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author Rawson, F. J.
Cole, M. T.
Hicks, J. M.
Aylott, J. W.
Milne, W. I.
Collins, C. M.
Jackson, S. K.
Silman, N. J.
Mendes, P. M.
author_facet Rawson, F. J.
Cole, M. T.
Hicks, J. M.
Aylott, J. W.
Milne, W. I.
Collins, C. M.
Jackson, S. K.
Silman, N. J.
Mendes, P. M.
author_sort Rawson, F. J.
collection PubMed
description With the rapidly increasing demands for ultrasensitive biodetection, the design and applications of new nano-scale materials for development of sensors based on optical and electrochemical transducers have attracted substantial interest. In particular, given the comparable sizes of nanomaterials and biomolecules, there exist plenty of opportunities to develop functional nanoprobes with biomolecules for highly sensitive and selective biosensing, shedding new light on cellular behaviour. Towards this aim, herein we interface cells with patterned nano-arrays of carbon nanofibers forming a nanosensor-cell construct. We show that such a construct is capable of electrochemically communicating with the intracellular environment.
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spelling pubmed-51313362016-12-15 Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes Rawson, F. J. Cole, M. T. Hicks, J. M. Aylott, J. W. Milne, W. I. Collins, C. M. Jackson, S. K. Silman, N. J. Mendes, P. M. Sci Rep Article With the rapidly increasing demands for ultrasensitive biodetection, the design and applications of new nano-scale materials for development of sensors based on optical and electrochemical transducers have attracted substantial interest. In particular, given the comparable sizes of nanomaterials and biomolecules, there exist plenty of opportunities to develop functional nanoprobes with biomolecules for highly sensitive and selective biosensing, shedding new light on cellular behaviour. Towards this aim, herein we interface cells with patterned nano-arrays of carbon nanofibers forming a nanosensor-cell construct. We show that such a construct is capable of electrochemically communicating with the intracellular environment. Nature Publishing Group 2016-12-01 /pmc/articles/PMC5131336/ /pubmed/27905472 http://dx.doi.org/10.1038/srep37672 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Rawson, F. J.
Cole, M. T.
Hicks, J. M.
Aylott, J. W.
Milne, W. I.
Collins, C. M.
Jackson, S. K.
Silman, N. J.
Mendes, P. M.
Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes
title Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes
title_full Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes
title_fullStr Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes
title_full_unstemmed Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes
title_short Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes
title_sort electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131336/
https://www.ncbi.nlm.nih.gov/pubmed/27905472
http://dx.doi.org/10.1038/srep37672
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