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In silico Mapping of Protein Unfolding Mutations for Inherited Disease
The effect of disease-causing missense mutations on protein folding is difficult to evaluate. To understand this relationship, we developed the unfolding mutation screen (UMS) for in silico evaluation of the severity of genetic perturbations at the atomic level of protein structure. The program take...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131339/ https://www.ncbi.nlm.nih.gov/pubmed/27905547 http://dx.doi.org/10.1038/srep37298 |