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Association between preterm brain injury and exposure to chorioamnionitis during fetal life
Preterm infants are susceptible to inflammation-induced white matter injury but the exposures that lead to this are uncertain. Histologic chorioamnionitis (HCA) reflects intrauterine inflammation, can trigger a fetal inflammatory response, and is closely associated with premature birth. In a cohort...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131360/ https://www.ncbi.nlm.nih.gov/pubmed/27905410 http://dx.doi.org/10.1038/srep37932 |
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author | Anblagan, Devasuda Pataky, Rozalia Evans, Margaret J. Telford, Emma J. Serag, Ahmed Sparrow, Sarah Piyasena, Chinthika Semple, Scott I. Wilkinson, Alastair Graham Bastin, Mark E. Boardman, James P. |
author_facet | Anblagan, Devasuda Pataky, Rozalia Evans, Margaret J. Telford, Emma J. Serag, Ahmed Sparrow, Sarah Piyasena, Chinthika Semple, Scott I. Wilkinson, Alastair Graham Bastin, Mark E. Boardman, James P. |
author_sort | Anblagan, Devasuda |
collection | PubMed |
description | Preterm infants are susceptible to inflammation-induced white matter injury but the exposures that lead to this are uncertain. Histologic chorioamnionitis (HCA) reflects intrauterine inflammation, can trigger a fetal inflammatory response, and is closely associated with premature birth. In a cohort of 90 preterm infants with detailed placental histology and neonatal brain magnetic resonance imaging (MRI) data at term equivalent age, we used Tract-based Spatial Statistics (TBSS) to perform voxel-wise statistical comparison of fractional anisotropy (FA) data and computational morphometry analysis to compute the volumes of whole brain, tissue compartments and cerebrospinal fluid, to test the hypothesis that HCA is an independent antenatal risk factor for preterm brain injury. Twenty-six (29%) infants had HCA and this was associated with decreased FA in the genu, cingulum cingulate gyri, centrum semiovale, inferior longitudinal fasciculi, limbs of the internal capsule, external capsule and cerebellum (p < 0.05, corrected), independent of degree of prematurity, bronchopulmonary dysplasia and postnatal sepsis. This suggests that diffuse white matter injury begins in utero for a significant proportion of preterm infants, which focuses attention on the development of methods for detecting fetuses and placentas at risk as a means of reducing preterm brain injury. |
format | Online Article Text |
id | pubmed-5131360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51313602016-12-15 Association between preterm brain injury and exposure to chorioamnionitis during fetal life Anblagan, Devasuda Pataky, Rozalia Evans, Margaret J. Telford, Emma J. Serag, Ahmed Sparrow, Sarah Piyasena, Chinthika Semple, Scott I. Wilkinson, Alastair Graham Bastin, Mark E. Boardman, James P. Sci Rep Article Preterm infants are susceptible to inflammation-induced white matter injury but the exposures that lead to this are uncertain. Histologic chorioamnionitis (HCA) reflects intrauterine inflammation, can trigger a fetal inflammatory response, and is closely associated with premature birth. In a cohort of 90 preterm infants with detailed placental histology and neonatal brain magnetic resonance imaging (MRI) data at term equivalent age, we used Tract-based Spatial Statistics (TBSS) to perform voxel-wise statistical comparison of fractional anisotropy (FA) data and computational morphometry analysis to compute the volumes of whole brain, tissue compartments and cerebrospinal fluid, to test the hypothesis that HCA is an independent antenatal risk factor for preterm brain injury. Twenty-six (29%) infants had HCA and this was associated with decreased FA in the genu, cingulum cingulate gyri, centrum semiovale, inferior longitudinal fasciculi, limbs of the internal capsule, external capsule and cerebellum (p < 0.05, corrected), independent of degree of prematurity, bronchopulmonary dysplasia and postnatal sepsis. This suggests that diffuse white matter injury begins in utero for a significant proportion of preterm infants, which focuses attention on the development of methods for detecting fetuses and placentas at risk as a means of reducing preterm brain injury. Nature Publishing Group 2016-12-01 /pmc/articles/PMC5131360/ /pubmed/27905410 http://dx.doi.org/10.1038/srep37932 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Anblagan, Devasuda Pataky, Rozalia Evans, Margaret J. Telford, Emma J. Serag, Ahmed Sparrow, Sarah Piyasena, Chinthika Semple, Scott I. Wilkinson, Alastair Graham Bastin, Mark E. Boardman, James P. Association between preterm brain injury and exposure to chorioamnionitis during fetal life |
title | Association between preterm brain injury and exposure to chorioamnionitis during fetal life |
title_full | Association between preterm brain injury and exposure to chorioamnionitis during fetal life |
title_fullStr | Association between preterm brain injury and exposure to chorioamnionitis during fetal life |
title_full_unstemmed | Association between preterm brain injury and exposure to chorioamnionitis during fetal life |
title_short | Association between preterm brain injury and exposure to chorioamnionitis during fetal life |
title_sort | association between preterm brain injury and exposure to chorioamnionitis during fetal life |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131360/ https://www.ncbi.nlm.nih.gov/pubmed/27905410 http://dx.doi.org/10.1038/srep37932 |
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