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Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity
BACKGROUND: Obesity-related insulin resistance is linked to inflammation. Immunometabolic function differs between lean and obese subjects, but whether macronutrient composition of ingested meals affects these responses is not well known. We examined the effects of a single meal rich in fat, protein...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131405/ https://www.ncbi.nlm.nih.gov/pubmed/27903298 http://dx.doi.org/10.1186/s12937-016-0219-0 |
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author | Parvaresh Rizi, Ehsan Baig, Sonia Shabeer, Muhammad Teo, Yvonne Mok, Shao Feng Loh, Tze Ping Magkos, Faidon Virtue, Sam Vidal-Puig, Antonio Tai, E. Shyong Khoo, Chin Meng Toh, Sue-Anne |
author_facet | Parvaresh Rizi, Ehsan Baig, Sonia Shabeer, Muhammad Teo, Yvonne Mok, Shao Feng Loh, Tze Ping Magkos, Faidon Virtue, Sam Vidal-Puig, Antonio Tai, E. Shyong Khoo, Chin Meng Toh, Sue-Anne |
author_sort | Parvaresh Rizi, Ehsan |
collection | PubMed |
description | BACKGROUND: Obesity-related insulin resistance is linked to inflammation. Immunometabolic function differs between lean and obese subjects, but whether macronutrient composition of ingested meals affects these responses is not well known. We examined the effects of a single meal rich in fat, protein, or carbohydrate on immunometabolic responses. METHODS: Nine lean insulin sensitive (LIS) men and 9 obese insulin resistant (OIR) men ingested high-carbohydrate (HC), high-fat (HF) or high-protein (HP) mixed meals in random order. We assessed plasma glucose, insulin, and cytokine responses and cytokine gene expression in circulating mononuclear cells (MNC) at fasting and postprandial states (up to 6-h). RESULTS: Expression of NF-κB and TNFα genes were greater; whereas that of TGFβ and IL-6 genes were lower, in the OIR compared to the LIS individuals. The differences were significantly greater after the HC meal, but not after the HP or HF meal. Similar results were obtained for plasma concentrations of TNFα and IL-6. CONCLUSIONS: Our findings indicate that a single HC meal has a distinct adverse effect on immunometabolic responses in the OIR individuals. The cumulative effect of such adverse responses to meals rich in carbohydrate may predispose the OIR individuals to a higher risk of cardiovascular disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12937-016-0219-0) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5131405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-51314052016-12-12 Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity Parvaresh Rizi, Ehsan Baig, Sonia Shabeer, Muhammad Teo, Yvonne Mok, Shao Feng Loh, Tze Ping Magkos, Faidon Virtue, Sam Vidal-Puig, Antonio Tai, E. Shyong Khoo, Chin Meng Toh, Sue-Anne Nutr J Research BACKGROUND: Obesity-related insulin resistance is linked to inflammation. Immunometabolic function differs between lean and obese subjects, but whether macronutrient composition of ingested meals affects these responses is not well known. We examined the effects of a single meal rich in fat, protein, or carbohydrate on immunometabolic responses. METHODS: Nine lean insulin sensitive (LIS) men and 9 obese insulin resistant (OIR) men ingested high-carbohydrate (HC), high-fat (HF) or high-protein (HP) mixed meals in random order. We assessed plasma glucose, insulin, and cytokine responses and cytokine gene expression in circulating mononuclear cells (MNC) at fasting and postprandial states (up to 6-h). RESULTS: Expression of NF-κB and TNFα genes were greater; whereas that of TGFβ and IL-6 genes were lower, in the OIR compared to the LIS individuals. The differences were significantly greater after the HC meal, but not after the HP or HF meal. Similar results were obtained for plasma concentrations of TNFα and IL-6. CONCLUSIONS: Our findings indicate that a single HC meal has a distinct adverse effect on immunometabolic responses in the OIR individuals. The cumulative effect of such adverse responses to meals rich in carbohydrate may predispose the OIR individuals to a higher risk of cardiovascular disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12937-016-0219-0) contains supplementary material, which is available to authorized users. BioMed Central 2016-12-01 /pmc/articles/PMC5131405/ /pubmed/27903298 http://dx.doi.org/10.1186/s12937-016-0219-0 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Parvaresh Rizi, Ehsan Baig, Sonia Shabeer, Muhammad Teo, Yvonne Mok, Shao Feng Loh, Tze Ping Magkos, Faidon Virtue, Sam Vidal-Puig, Antonio Tai, E. Shyong Khoo, Chin Meng Toh, Sue-Anne Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity |
title | Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity |
title_full | Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity |
title_fullStr | Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity |
title_full_unstemmed | Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity |
title_short | Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity |
title_sort | meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131405/ https://www.ncbi.nlm.nih.gov/pubmed/27903298 http://dx.doi.org/10.1186/s12937-016-0219-0 |
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