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Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

BACKGROUND: α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson’s disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic to neurons. In the brain, microglial αSYN clearance is closely related to neuro...

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Detalles Bibliográficos
Autores principales:	Maekawa, Tatsunori, Sasaoka, Toshikuni, Azuma, Sadahiro, Ichikawa, Takafumi, Melrose, Heather L., Farrer, Matthew J., Obata, Fumiya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131420/ https://www.ncbi.nlm.nih.gov/pubmed/27903237 http://dx.doi.org/10.1186/s12868-016-0315-2

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