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The predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in FNA – single centre prospective study

BACKGROUND: To determine the diagnostic efficacy of ultrasonographic malignancy risk features (UMRFs) in follicular lesions (FL) in a population with low risk of malignancy in FL and to compare it with a similar analysis in a group of patients with unequivocal cytology (UC): benign lesion (BL) or ma...

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Autores principales: Słowińska-Klencka, Dorota, Wojtaszek-Nowicka, Martyna, Sporny, Stanisław, Woźniak-Oseła, Ewa, Popowicz, Bożena, Klencki, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131422/
https://www.ncbi.nlm.nih.gov/pubmed/27903245
http://dx.doi.org/10.1186/s12902-016-0151-5
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author Słowińska-Klencka, Dorota
Wojtaszek-Nowicka, Martyna
Sporny, Stanisław
Woźniak-Oseła, Ewa
Popowicz, Bożena
Klencki, Mariusz
author_facet Słowińska-Klencka, Dorota
Wojtaszek-Nowicka, Martyna
Sporny, Stanisław
Woźniak-Oseła, Ewa
Popowicz, Bożena
Klencki, Mariusz
author_sort Słowińska-Klencka, Dorota
collection PubMed
description BACKGROUND: To determine the diagnostic efficacy of ultrasonographic malignancy risk features (UMRFs) in follicular lesions (FL) in a population with low risk of malignancy in FL and to compare it with a similar analysis in a group of patients with unequivocal cytology (UC): benign lesion (BL) or malignant neoplasm (MN). METHODS: Presence of UMRFs (hypoechogenicity, solid echostructure, taller-than-wide shape, pathological vascularization, irregular margins, microcalcifications and macrocalcifications) and their sets were assessed in 322 FL: 202 follicular lesions of undetermined significance (FLUS) and 120 suspicious for follicular neoplasm (SFN) and 300 nodules with UC: 200 BL and 100 MN, subsequently evaluated histopathologically. RESULTS: Cancers were confirmed in 100% nodules in MN group (89.0% of them were papillary carcinomas - PTC), in 6.4% FLUS nodules (69.2% PTC), and in 10.8% SFN nodules (30.8% PTC). In the UC group all UMRFs occurred more frequently in cancers than in benign lesions. In the FL group only calcifications were found in cancers more frequently – macro and microcalcifications together: 34.6 vs. 11.5% (p = 0.001) and isolated macrocalcifications: 26.0 vs. 6.8% (p = 0.001); the presence of those features increased the basic risk of malignancy in FL more than 2 times. The presence of at least 2 of the following URMFs: hypoechogenicity, solid echostructure, any type of calcifications and suspected shape, additionally improved sensitivity. CONCLUSIONS: Evaluation of UMRFs in FLs is less effective than in nodules with UC, and its effectiveness decreases parallel to the decrease in percentage of PTCs among malignant neoplasms and to the increase of the percentage of adenomas among benign nodules. The presence of macrocalcifications in such FLs significantly increases the basic risk of malignancy in these nodules.
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spelling pubmed-51314222016-12-12 The predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in FNA – single centre prospective study Słowińska-Klencka, Dorota Wojtaszek-Nowicka, Martyna Sporny, Stanisław Woźniak-Oseła, Ewa Popowicz, Bożena Klencki, Mariusz BMC Endocr Disord Research Article BACKGROUND: To determine the diagnostic efficacy of ultrasonographic malignancy risk features (UMRFs) in follicular lesions (FL) in a population with low risk of malignancy in FL and to compare it with a similar analysis in a group of patients with unequivocal cytology (UC): benign lesion (BL) or malignant neoplasm (MN). METHODS: Presence of UMRFs (hypoechogenicity, solid echostructure, taller-than-wide shape, pathological vascularization, irregular margins, microcalcifications and macrocalcifications) and their sets were assessed in 322 FL: 202 follicular lesions of undetermined significance (FLUS) and 120 suspicious for follicular neoplasm (SFN) and 300 nodules with UC: 200 BL and 100 MN, subsequently evaluated histopathologically. RESULTS: Cancers were confirmed in 100% nodules in MN group (89.0% of them were papillary carcinomas - PTC), in 6.4% FLUS nodules (69.2% PTC), and in 10.8% SFN nodules (30.8% PTC). In the UC group all UMRFs occurred more frequently in cancers than in benign lesions. In the FL group only calcifications were found in cancers more frequently – macro and microcalcifications together: 34.6 vs. 11.5% (p = 0.001) and isolated macrocalcifications: 26.0 vs. 6.8% (p = 0.001); the presence of those features increased the basic risk of malignancy in FL more than 2 times. The presence of at least 2 of the following URMFs: hypoechogenicity, solid echostructure, any type of calcifications and suspected shape, additionally improved sensitivity. CONCLUSIONS: Evaluation of UMRFs in FLs is less effective than in nodules with UC, and its effectiveness decreases parallel to the decrease in percentage of PTCs among malignant neoplasms and to the increase of the percentage of adenomas among benign nodules. The presence of macrocalcifications in such FLs significantly increases the basic risk of malignancy in these nodules. BioMed Central 2016-12-01 /pmc/articles/PMC5131422/ /pubmed/27903245 http://dx.doi.org/10.1186/s12902-016-0151-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Słowińska-Klencka, Dorota
Wojtaszek-Nowicka, Martyna
Sporny, Stanisław
Woźniak-Oseła, Ewa
Popowicz, Bożena
Klencki, Mariusz
The predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in FNA – single centre prospective study
title The predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in FNA – single centre prospective study
title_full The predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in FNA – single centre prospective study
title_fullStr The predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in FNA – single centre prospective study
title_full_unstemmed The predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in FNA – single centre prospective study
title_short The predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in FNA – single centre prospective study
title_sort predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in fna – single centre prospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131422/
https://www.ncbi.nlm.nih.gov/pubmed/27903245
http://dx.doi.org/10.1186/s12902-016-0151-5
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