Pazopanib: a novel treatment option for aggressive fibromatosis

BACKGROUND: Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it is locally invasive and its propensity for recurrence after conservative resection is well documented. No effective cytotoxic treatment has been reported, hence...

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Autores principales: Bulut, Gulcan, Ozluk, Anil, Erdogan, Atike Pınar, Uslu, Ruchan, Elmas, Nevra, Karaca, Burcak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131445/
https://www.ncbi.nlm.nih.gov/pubmed/27957320
http://dx.doi.org/10.1186/s13569-016-0061-3
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author Bulut, Gulcan
Ozluk, Anil
Erdogan, Atike Pınar
Uslu, Ruchan
Elmas, Nevra
Karaca, Burcak
author_facet Bulut, Gulcan
Ozluk, Anil
Erdogan, Atike Pınar
Uslu, Ruchan
Elmas, Nevra
Karaca, Burcak
author_sort Bulut, Gulcan
collection PubMed
description BACKGROUND: Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it is locally invasive and its propensity for recurrence after conservative resection is well documented. No effective cytotoxic treatment has been reported, hence there is a need for novel treatment strategies. CASE PRESENTATION: We present the case of an AF successfully treated with an oral tyrosine kinase inhibitor, pazopanib, with mild side effects. As far as we know, this is the first case of AF with complete response to pazopanib. CONCLUSION: Pazopanib might be an effective treatment option for AF.
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spelling pubmed-51314452016-12-12 Pazopanib: a novel treatment option for aggressive fibromatosis Bulut, Gulcan Ozluk, Anil Erdogan, Atike Pınar Uslu, Ruchan Elmas, Nevra Karaca, Burcak Clin Sarcoma Res Case Report BACKGROUND: Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it is locally invasive and its propensity for recurrence after conservative resection is well documented. No effective cytotoxic treatment has been reported, hence there is a need for novel treatment strategies. CASE PRESENTATION: We present the case of an AF successfully treated with an oral tyrosine kinase inhibitor, pazopanib, with mild side effects. As far as we know, this is the first case of AF with complete response to pazopanib. CONCLUSION: Pazopanib might be an effective treatment option for AF. BioMed Central 2016-12-01 /pmc/articles/PMC5131445/ /pubmed/27957320 http://dx.doi.org/10.1186/s13569-016-0061-3 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Bulut, Gulcan
Ozluk, Anil
Erdogan, Atike Pınar
Uslu, Ruchan
Elmas, Nevra
Karaca, Burcak
Pazopanib: a novel treatment option for aggressive fibromatosis
title Pazopanib: a novel treatment option for aggressive fibromatosis
title_full Pazopanib: a novel treatment option for aggressive fibromatosis
title_fullStr Pazopanib: a novel treatment option for aggressive fibromatosis
title_full_unstemmed Pazopanib: a novel treatment option for aggressive fibromatosis
title_short Pazopanib: a novel treatment option for aggressive fibromatosis
title_sort pazopanib: a novel treatment option for aggressive fibromatosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131445/
https://www.ncbi.nlm.nih.gov/pubmed/27957320
http://dx.doi.org/10.1186/s13569-016-0061-3
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