A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme

Regulation of deubiquitinating enzyme (DUB) activity is an essential step for proper function of cellular ubiquitin signals. UAF1 is a WD40 repeat protein, which binds and activates three important DUBs, USP1, USP12 and USP46. Here, we report the crystal structure of the USP12-Ub/UAF1 complex at a r...

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Detalles Bibliográficos
Autores principales: Dharadhar, Shreya, Clerici, Marcello, van Dijk, Willem J., Fish, Alexander, Sixma, Titia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131612/
https://www.ncbi.nlm.nih.gov/pubmed/27650958
http://dx.doi.org/10.1016/j.jsb.2016.09.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131612/
https://www.ncbi.nlm.nih.gov/pubmed/27650958
http://dx.doi.org/10.1016/j.jsb.2016.09.011

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