Cargando…
The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2)
Age-related Macular Degeneration (AMD) is a common, irreversible blinding condition that leads to the loss of central vision. AMD has a complex aetiology with both genetic as well as environmental risks factors, and share many similarities with Alzheimer's disease. Recent findings have contribu...
Autores principales: | Taylor-Walker, George, Lynn, Savannah A., Keeling, Eloise, Munday, Rosie, Johnston, David A., Page, Anton, Scott, Jennifer A., Goverdhan, Srini, Lotery, Andrew J., Ratnayaka, J. Arjuna |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131630/ https://www.ncbi.nlm.nih.gov/pubmed/27751744 http://dx.doi.org/10.1016/j.exer.2016.10.013 |
Ejemplares similares
-
The complexities underlying age-related macular degeneration: could amyloid beta play an important role?
por: Lynn, Savannah A., et al.
Publicado: (2017) -
Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases
por: Keeling, Eloise, et al.
Publicado: (2018) -
An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy
por: Keeling, Eloise, et al.
Publicado: (2020) -
A convenient protocol for establishing a human cell culture model of the outer retina.
por: Lynn, Savannah A., et al.
Publicado: (2018) -
Oligomeric Aβ(1-42) Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function
por: Lynn, Savannah A., et al.
Publicado: (2021)