Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans

Immunoglobulin G (IgG) mediates its immune functions through complement and cellular IgG-Fc receptors (FcγR). IgG contains an evolutionary conserved N-linked glycan at position Asn297 in the Fc-domain. This glycan consists of variable levels of fucose, galactose, sialic acid, and bisecting N-acetylg...

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Detalles Bibliográficos
Autores principales: Dekkers, Gillian, Plomp, Rosina, Koeleman, Carolien A. M., Visser, Remco, von Horsten, Hans H., Sandig, Volker, Rispens, Theo, Wuhrer, Manfred, Vidarsson, Gestur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131652/
https://www.ncbi.nlm.nih.gov/pubmed/27872474
http://dx.doi.org/10.1038/srep36964

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