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Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation

Methylated cytosines are associated with gene silencing. The ten-eleven translocation (TET) hydroxylases, which oxidize methylated cytosines to 5-hydroxymethylcytosine (5hmC), are essential for cytosine demethylation. Gene silencing and activation are critical for intestinal stem cell (ISC) maintena...

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Detalles Bibliográficos
Autores principales:	Kim, Rinho, Sheaffer, Karyn L., Choi, Inchan, Won, Kyoung-Jae, Kaestner, Klaus H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131782/ https://www.ncbi.nlm.nih.gov/pubmed/27856615 http://dx.doi.org/10.1101/gad.288035.116

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