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Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population
Genetic variants that disrupt protein-coding DNA are ubiquitous in the human population, with about 100 such loss-of-function variants per individual. While most loss-of-function variants are rare, a subset have risen to high frequency and occur in a homozygous state in healthy individuals. It is un...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131816/ https://www.ncbi.nlm.nih.gov/pubmed/27646533 http://dx.doi.org/10.1101/gr.205070.116 |