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Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America; we detected 8 loci (P<5x10(–8)), 7 of which are novel for these cancer sites. Oral and pharyngeal cancers combined were associated with...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131845/ https://www.ncbi.nlm.nih.gov/pubmed/27749845 http://dx.doi.org/10.1038/ng.3685 |
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| author | Lesseur, Corina Diergaarde, Brenda Olshan, Andrew F Wünsch-Filho, Victor Ness, Andrew R Liu, Geoffrey Lacko, Martin Eluf-Neto, José Franceschi, Silvia Lagiou, Pagona Macfarlane, Gary J Richiardi, Lorenzo Boccia, Stefania Polesel, Jerry Kjaerheim, Kristina Zaridze, David Johansson, Mattias Menezes, Ana M Curado, Maria Paula Robinson, Max Ahrens, Wolfgang Canova, Cristina Znaor, Ariana Castellsagué, Xavier Conway, David I Holcátová, Ivana Mates, Dana Vilensky, Marta Healy, Claire M Szeszenia-Dąbrowska, Neonila Fabiánová, Eleonóra Lissowska, Jolanta Grandis, Jennifer R Weissler, Mark C Tajara, Eloiza H Nunes, Fabio D de Carvalho, Marcos B Thomas, Steve Hung, Rayjean J Peters, Wilbert H M Herrero, Rolando Cadoni, Gabriella Bueno-de-Mesquita, H Bas Steffen, Annika Agudo, Antonio Shangina, Oxana Xiao, Xiangjun Gaborieau, Valérie Chabrier, Amélie Anantharaman, Devasena Boffetta, Paolo Amos, Christopher I McKay, James D Brennan, Paul |
| author_facet | Lesseur, Corina Diergaarde, Brenda Olshan, Andrew F Wünsch-Filho, Victor Ness, Andrew R Liu, Geoffrey Lacko, Martin Eluf-Neto, José Franceschi, Silvia Lagiou, Pagona Macfarlane, Gary J Richiardi, Lorenzo Boccia, Stefania Polesel, Jerry Kjaerheim, Kristina Zaridze, David Johansson, Mattias Menezes, Ana M Curado, Maria Paula Robinson, Max Ahrens, Wolfgang Canova, Cristina Znaor, Ariana Castellsagué, Xavier Conway, David I Holcátová, Ivana Mates, Dana Vilensky, Marta Healy, Claire M Szeszenia-Dąbrowska, Neonila Fabiánová, Eleonóra Lissowska, Jolanta Grandis, Jennifer R Weissler, Mark C Tajara, Eloiza H Nunes, Fabio D de Carvalho, Marcos B Thomas, Steve Hung, Rayjean J Peters, Wilbert H M Herrero, Rolando Cadoni, Gabriella Bueno-de-Mesquita, H Bas Steffen, Annika Agudo, Antonio Shangina, Oxana Xiao, Xiangjun Gaborieau, Valérie Chabrier, Amélie Anantharaman, Devasena Boffetta, Paolo Amos, Christopher I McKay, James D Brennan, Paul |
| author_sort | Lesseur, Corina |
| collection | PubMed |
| description | We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America; we detected 8 loci (P<5x10(–8)), 7 of which are novel for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2/TRIM5). Oral cancer was associated with two new regions 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer loci: 9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region and classical HLA allele imputation revealed a protective association with the class II haplotype DRB1*1301-DQA1*0103-DQB1*0603 (odds ratio (OR)=0.59, P=2.7x10(–9)). Stratified analyses on a subgroup of oropharyngeal cases with human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR=0.23, P=1.6x10(–6)) compared to HPV-negative cancers (OR=0.75, P=0.16). |
| format | Online Article Text |
| id | pubmed-5131845 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-51318452017-04-17 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer Lesseur, Corina Diergaarde, Brenda Olshan, Andrew F Wünsch-Filho, Victor Ness, Andrew R Liu, Geoffrey Lacko, Martin Eluf-Neto, José Franceschi, Silvia Lagiou, Pagona Macfarlane, Gary J Richiardi, Lorenzo Boccia, Stefania Polesel, Jerry Kjaerheim, Kristina Zaridze, David Johansson, Mattias Menezes, Ana M Curado, Maria Paula Robinson, Max Ahrens, Wolfgang Canova, Cristina Znaor, Ariana Castellsagué, Xavier Conway, David I Holcátová, Ivana Mates, Dana Vilensky, Marta Healy, Claire M Szeszenia-Dąbrowska, Neonila Fabiánová, Eleonóra Lissowska, Jolanta Grandis, Jennifer R Weissler, Mark C Tajara, Eloiza H Nunes, Fabio D de Carvalho, Marcos B Thomas, Steve Hung, Rayjean J Peters, Wilbert H M Herrero, Rolando Cadoni, Gabriella Bueno-de-Mesquita, H Bas Steffen, Annika Agudo, Antonio Shangina, Oxana Xiao, Xiangjun Gaborieau, Valérie Chabrier, Amélie Anantharaman, Devasena Boffetta, Paolo Amos, Christopher I McKay, James D Brennan, Paul Nat Genet Article We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America; we detected 8 loci (P<5x10(–8)), 7 of which are novel for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2/TRIM5). Oral cancer was associated with two new regions 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer loci: 9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region and classical HLA allele imputation revealed a protective association with the class II haplotype DRB1*1301-DQA1*0103-DQB1*0603 (odds ratio (OR)=0.59, P=2.7x10(–9)). Stratified analyses on a subgroup of oropharyngeal cases with human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR=0.23, P=1.6x10(–6)) compared to HPV-negative cancers (OR=0.75, P=0.16). 2016-10-17 2016-12 /pmc/articles/PMC5131845/ /pubmed/27749845 http://dx.doi.org/10.1038/ng.3685 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Lesseur, Corina Diergaarde, Brenda Olshan, Andrew F Wünsch-Filho, Victor Ness, Andrew R Liu, Geoffrey Lacko, Martin Eluf-Neto, José Franceschi, Silvia Lagiou, Pagona Macfarlane, Gary J Richiardi, Lorenzo Boccia, Stefania Polesel, Jerry Kjaerheim, Kristina Zaridze, David Johansson, Mattias Menezes, Ana M Curado, Maria Paula Robinson, Max Ahrens, Wolfgang Canova, Cristina Znaor, Ariana Castellsagué, Xavier Conway, David I Holcátová, Ivana Mates, Dana Vilensky, Marta Healy, Claire M Szeszenia-Dąbrowska, Neonila Fabiánová, Eleonóra Lissowska, Jolanta Grandis, Jennifer R Weissler, Mark C Tajara, Eloiza H Nunes, Fabio D de Carvalho, Marcos B Thomas, Steve Hung, Rayjean J Peters, Wilbert H M Herrero, Rolando Cadoni, Gabriella Bueno-de-Mesquita, H Bas Steffen, Annika Agudo, Antonio Shangina, Oxana Xiao, Xiangjun Gaborieau, Valérie Chabrier, Amélie Anantharaman, Devasena Boffetta, Paolo Amos, Christopher I McKay, James D Brennan, Paul Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer |
| title | Genome-wide association analyses identify new susceptibility loci for
oral cavity and pharyngeal cancer |
| title_full | Genome-wide association analyses identify new susceptibility loci for
oral cavity and pharyngeal cancer |
| title_fullStr | Genome-wide association analyses identify new susceptibility loci for
oral cavity and pharyngeal cancer |
| title_full_unstemmed | Genome-wide association analyses identify new susceptibility loci for
oral cavity and pharyngeal cancer |
| title_short | Genome-wide association analyses identify new susceptibility loci for
oral cavity and pharyngeal cancer |
| title_sort | genome-wide association analyses identify new susceptibility loci for
oral cavity and pharyngeal cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131845/ https://www.ncbi.nlm.nih.gov/pubmed/27749845 http://dx.doi.org/10.1038/ng.3685 |
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