Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling

The investigational ticagrelor‐neutralizing antibody fragment, MEDI2452, is developed to rapidly and specifically reverse the antiplatelet effects of ticagrelor. However, the dynamic interaction of ticagrelor, the ticagrelor active metabolite (TAM), and MEDI2452, makes pharmacokinetic (PK) analysis...

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Detalles Bibliográficos
Autores principales: Almquist, J, Penney, M, Pehrsson, S, Sandinge, A‐S, Janefeldt, A, Maqbool, S, Madalli, S, Goodman, J, Nylander, S, Gennemark, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131888/
https://www.ncbi.nlm.nih.gov/pubmed/27310493
http://dx.doi.org/10.1002/psp4.12089

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