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B Cell-Based Seamless Engineering of Antibody Fc Domains

Engineering of monoclonal antibodies (mAbs) enables us to obtain mAbs with additional functions. In particular, modifications in antibody’s Fc (fragment, crystallizable) region can provide multiple benefits such as added toxicity by drug conjugation, higher affinity to Fc receptors on immunocytes, o...

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Detalles Bibliográficos
Autores principales:	Hashimoto, Koji, Kurosawa, Kohei, Murayama, Akiho, Seo, Hidetaka, Ohta, Kunihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131995/ https://www.ncbi.nlm.nih.gov/pubmed/27907066 http://dx.doi.org/10.1371/journal.pone.0167232

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