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Probing Functional Heteromeric Chemokine Protein–Protein Interactions through Conformation‐Assisted Oxime Ligation

Protein–protein interactions (PPIs) govern most processes in living cells. Current drug development strategies are aimed at disrupting or stabilizing PPIs, which require a thorough understanding of PPI mechanisms. Examples of such PPIs are heteromeric chemokine interactions that are potentially invo...

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Detalles Bibliográficos
Autores principales: Agten, Stijn M., Koenen, Rory R., Ippel, Hans, Eckardt, Veit, von Hundelshausen, Philipp, Mayo, Kevin H., Weber, Christian, Hackeng, Tilman M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132021/
https://www.ncbi.nlm.nih.gov/pubmed/27785869
http://dx.doi.org/10.1002/anie.201607036