Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated

Small GTPases in the Rho family act as major nodes with functions beyond cytoskeletal rearrangements shaping the Caenorhabditis elegans embryo during development. These small GTPases are key signal transducers that integrate diverse developmental signals to produce a coordinated response in the cell...

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Autores principales: Sáenz‐Narciso, Beatriz, Gómez‐Orte, Eva, Zheleva, Angelina, Gastaca, Irene, Cabello, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Prospects & Overviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132145/
https://www.ncbi.nlm.nih.gov/pubmed/27790724
http://dx.doi.org/10.1002/bies.201600165
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author Sáenz‐Narciso, Beatriz
Gómez‐Orte, Eva
Zheleva, Angelina
Gastaca, Irene
Cabello, Juan
author_facet Sáenz‐Narciso, Beatriz
Gómez‐Orte, Eva
Zheleva, Angelina
Gastaca, Irene
Cabello, Juan
author_sort Sáenz‐Narciso, Beatriz
collection PubMed
description Small GTPases in the Rho family act as major nodes with functions beyond cytoskeletal rearrangements shaping the Caenorhabditis elegans embryo during development. These small GTPases are key signal transducers that integrate diverse developmental signals to produce a coordinated response in the cell. In C. elegans, the best studied members of these highly conserved Rho family small GTPases, RHO‐1/RhoA, CED‐10/Rac, and CDC‐42, are crucial in several cellular processes dealing with cytoskeletal reorganization. In this review, we update the functions described for the Rho family small GTPases in spindle orientation and cell division, engulfment, and cellular movements during C. elegans embryogenesis, focusing on the Rho subfamily Rac. Please also see the video abstract here
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spelling pubmed-51321452016-12-19 Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated Sáenz‐Narciso, Beatriz Gómez‐Orte, Eva Zheleva, Angelina Gastaca, Irene Cabello, Juan Bioessays Prospects & Overviews Small GTPases in the Rho family act as major nodes with functions beyond cytoskeletal rearrangements shaping the Caenorhabditis elegans embryo during development. These small GTPases are key signal transducers that integrate diverse developmental signals to produce a coordinated response in the cell. In C. elegans, the best studied members of these highly conserved Rho family small GTPases, RHO‐1/RhoA, CED‐10/Rac, and CDC‐42, are crucial in several cellular processes dealing with cytoskeletal reorganization. In this review, we update the functions described for the Rho family small GTPases in spindle orientation and cell division, engulfment, and cellular movements during C. elegans embryogenesis, focusing on the Rho subfamily Rac. Please also see the video abstract here John Wiley and Sons Inc. 2016-10-28 2016-12 /pmc/articles/PMC5132145/ /pubmed/27790724 http://dx.doi.org/10.1002/bies.201600165 Text en © 2016 The Authors BioEssays Published by WILEY Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Prospects & Overviews
Sáenz‐Narciso, Beatriz
Gómez‐Orte, Eva
Zheleva, Angelina
Gastaca, Irene
Cabello, Juan
Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated
title Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated
title_full Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated
title_fullStr Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated
title_full_unstemmed Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated
title_short Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated
title_sort control of developmental networks by rac/rho small gtpases: how cytoskeletal changes during embryogenesis are orchestrated
topic Prospects & Overviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132145/
https://www.ncbi.nlm.nih.gov/pubmed/27790724
http://dx.doi.org/10.1002/bies.201600165
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