Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma

Human mucosal melanoma (MM), an uncommon, aggressive and diverse subtype, shares characteristics with spontaneous MM in dogs. Although BRAF and N‐RAS mutations are uncommon in MM in both species, the majority of human and canine MM evaluated exhibited RAS/ERK and/or PI3K/mTOR signaling pathway activ...

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Detalles Bibliográficos
Autores principales: Wei, Bih‐Rong, Michael, Helen T., Halsey, Charles H.C., Peer, Cody J., Adhikari, Amit, Dwyer, Jennifer E., Hoover, Shelley B., El Meskini, Rajaa, Kozlov, Serguei, Weaver Ohler, Zoe, Figg, William. D., Merlino, Glenn, Simpson, R. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132162/
https://www.ncbi.nlm.nih.gov/pubmed/27463366
http://dx.doi.org/10.1111/pcmr.12512

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