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Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics

Serotonin transporter (SERT) modulates serotonergic signaling via re-uptake of serotonin in pre-synaptic cells. The inclusion in cholesterol-enriched membrane domains is crucial for SERT activity, suggesting a cross-talk between the protein and the sterol. Here, we develop a protocol to identify pot...

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Detalles Bibliográficos
Autores principales:	Ferraro, Mariarosaria, Masetti, Matteo, Recanatini, Maurizio, Cavalli, Andrea, Bottegoni, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132266/ https://www.ncbi.nlm.nih.gov/pubmed/27907003 http://dx.doi.org/10.1371/journal.pone.0166196

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