Fhit loss‐associated initiation and progression of neoplasia in vitro

The FHIT gene, encompassing an active common fragile site, FRA3B, is frequently silenced in preneoplasia and cancer, through gene rearrangement or methylation of regulatory sequences. Silencing of Fhit protein expression causes thymidine kinase 1 downregulation, resulting in dNTP imbalance, and spon...

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Detalles Bibliográficos
Autores principales: Karras, Jenna R., Schrock, Morgan S., Batar, Bahadir, Zhang, Jie, La Perle, Krista, Druck, Teresa, Huebner, Kay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132276/
https://www.ncbi.nlm.nih.gov/pubmed/27513973
http://dx.doi.org/10.1111/cas.13032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132276/
https://www.ncbi.nlm.nih.gov/pubmed/27513973
http://dx.doi.org/10.1111/cas.13032

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