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Intensity‐specific effect of physical activity on urinary levels of 8‐hydroxydeoxyguanosine in middle‐aged Japanese

Physical activity (PA) is recommended to both promote and maintain health and prevent cancer by improving the body's DNA repair system, which is considered a mechanism of cancer prevention. However, associations between PA and urinary levels of 8‐hydroxydeoxyguanosine (8‐OH‐dG), which reflects...

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Autores principales: Hara, Megumi, Nishida, Yuichiro, Shimanoe, Chisato, Otsuka, Yasuko, Nanri, Hinako, Yasukata, Jun, Miyoshi, Nobuyuki, Yamada, Yosuke, Horita, Mikako, Kawai, Kazuaki, Li, Yun‐Shan, Kasai, Jun, Kasai, Hiroshi, Higaki, Yasuki, Tanaka, Keitaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132284/
https://www.ncbi.nlm.nih.gov/pubmed/27575995
http://dx.doi.org/10.1111/cas.13070
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author Hara, Megumi
Nishida, Yuichiro
Shimanoe, Chisato
Otsuka, Yasuko
Nanri, Hinako
Yasukata, Jun
Miyoshi, Nobuyuki
Yamada, Yosuke
Horita, Mikako
Kawai, Kazuaki
Li, Yun‐Shan
Kasai, Jun
Kasai, Hiroshi
Higaki, Yasuki
Tanaka, Keitaro
author_facet Hara, Megumi
Nishida, Yuichiro
Shimanoe, Chisato
Otsuka, Yasuko
Nanri, Hinako
Yasukata, Jun
Miyoshi, Nobuyuki
Yamada, Yosuke
Horita, Mikako
Kawai, Kazuaki
Li, Yun‐Shan
Kasai, Jun
Kasai, Hiroshi
Higaki, Yasuki
Tanaka, Keitaro
author_sort Hara, Megumi
collection PubMed
description Physical activity (PA) is recommended to both promote and maintain health and prevent cancer by improving the body's DNA repair system, which is considered a mechanism of cancer prevention. However, associations between PA and urinary levels of 8‐hydroxydeoxyguanosine (8‐OH‐dG), which reflects DNA damage, are unclear. This cross‐sectional study included 2370 men and 4052 women aged 45–74 years enrolled between 2010 and 2012. Habitual PA was assessed by single‐axis accelerometer and urinary 8‐OH‐dG levels by automated HPLC. Multiple linear regression analysis was used to examine the relationship between log‐transformed urinary 8‐OH‐dG and total PA (TPA) and PA of moderate/vigorous intensity (MVPA; ≥3 metabolic equivalents), with adjustment for age, body mass index, energy intake, alcohol consumption, smoking status, daily coffee drinking, menopause status (in women), and TPA (for MVPA). On multivariate adjustment, urinary 8‐OH‐dG levels were inversely correlated with TPA (β = −0.020, P < 0.01) in women, and this correlation was not changed by PA intensity. Conversely, urinary 8‐OH‐dG levels were inversely correlated with MVPA (β = −0.022, P < 0.05) in men, although the correlation with TPA was non‐significant. This inverse correlation was clearer in current smokers than in never or former smokers, although the interaction between smoking status and MVPA on urinary 8‐OH‐dG levels was non‐significant. In conclusion, greater TPA in women and greater MVPA in men were correlated with reduction in urinary 8‐OH‐dG, suggesting sex‐specific effects of MVPA and TPA on protection from oxidative DNA damage. Increasing PA may mediate reduction in oxidative stress.
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spelling pubmed-51322842016-12-15 Intensity‐specific effect of physical activity on urinary levels of 8‐hydroxydeoxyguanosine in middle‐aged Japanese Hara, Megumi Nishida, Yuichiro Shimanoe, Chisato Otsuka, Yasuko Nanri, Hinako Yasukata, Jun Miyoshi, Nobuyuki Yamada, Yosuke Horita, Mikako Kawai, Kazuaki Li, Yun‐Shan Kasai, Jun Kasai, Hiroshi Higaki, Yasuki Tanaka, Keitaro Cancer Sci Original Articles Physical activity (PA) is recommended to both promote and maintain health and prevent cancer by improving the body's DNA repair system, which is considered a mechanism of cancer prevention. However, associations between PA and urinary levels of 8‐hydroxydeoxyguanosine (8‐OH‐dG), which reflects DNA damage, are unclear. This cross‐sectional study included 2370 men and 4052 women aged 45–74 years enrolled between 2010 and 2012. Habitual PA was assessed by single‐axis accelerometer and urinary 8‐OH‐dG levels by automated HPLC. Multiple linear regression analysis was used to examine the relationship between log‐transformed urinary 8‐OH‐dG and total PA (TPA) and PA of moderate/vigorous intensity (MVPA; ≥3 metabolic equivalents), with adjustment for age, body mass index, energy intake, alcohol consumption, smoking status, daily coffee drinking, menopause status (in women), and TPA (for MVPA). On multivariate adjustment, urinary 8‐OH‐dG levels were inversely correlated with TPA (β = −0.020, P < 0.01) in women, and this correlation was not changed by PA intensity. Conversely, urinary 8‐OH‐dG levels were inversely correlated with MVPA (β = −0.022, P < 0.05) in men, although the correlation with TPA was non‐significant. This inverse correlation was clearer in current smokers than in never or former smokers, although the interaction between smoking status and MVPA on urinary 8‐OH‐dG levels was non‐significant. In conclusion, greater TPA in women and greater MVPA in men were correlated with reduction in urinary 8‐OH‐dG, suggesting sex‐specific effects of MVPA and TPA on protection from oxidative DNA damage. Increasing PA may mediate reduction in oxidative stress. John Wiley and Sons Inc. 2016-11-29 2016-11 /pmc/articles/PMC5132284/ /pubmed/27575995 http://dx.doi.org/10.1111/cas.13070 Text en © 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Hara, Megumi
Nishida, Yuichiro
Shimanoe, Chisato
Otsuka, Yasuko
Nanri, Hinako
Yasukata, Jun
Miyoshi, Nobuyuki
Yamada, Yosuke
Horita, Mikako
Kawai, Kazuaki
Li, Yun‐Shan
Kasai, Jun
Kasai, Hiroshi
Higaki, Yasuki
Tanaka, Keitaro
Intensity‐specific effect of physical activity on urinary levels of 8‐hydroxydeoxyguanosine in middle‐aged Japanese
title Intensity‐specific effect of physical activity on urinary levels of 8‐hydroxydeoxyguanosine in middle‐aged Japanese
title_full Intensity‐specific effect of physical activity on urinary levels of 8‐hydroxydeoxyguanosine in middle‐aged Japanese
title_fullStr Intensity‐specific effect of physical activity on urinary levels of 8‐hydroxydeoxyguanosine in middle‐aged Japanese
title_full_unstemmed Intensity‐specific effect of physical activity on urinary levels of 8‐hydroxydeoxyguanosine in middle‐aged Japanese
title_short Intensity‐specific effect of physical activity on urinary levels of 8‐hydroxydeoxyguanosine in middle‐aged Japanese
title_sort intensity‐specific effect of physical activity on urinary levels of 8‐hydroxydeoxyguanosine in middle‐aged japanese
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132284/
https://www.ncbi.nlm.nih.gov/pubmed/27575995
http://dx.doi.org/10.1111/cas.13070
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