AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin

AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I and II clinical trials for the treatment of several cancers. However, the mechanisms by which AS1411 targets and kills glioma cells and tissues remain unclear. Here we report that AS1411 induces cell apoptosi...

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Detalles Bibliográficos
Autores principales: Cheng, Ye, Zhao, Gang, Zhang, Siwen, Nigim, Fares, Zhou, Guangtong, Yu, Zhiyun, Song, Yang, Chen, Yong, Li, Yunqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132312/
https://www.ncbi.nlm.nih.gov/pubmed/27907160
http://dx.doi.org/10.1371/journal.pone.0167094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132312/
https://www.ncbi.nlm.nih.gov/pubmed/27907160
http://dx.doi.org/10.1371/journal.pone.0167094

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