Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism

Elevated pancreatic β-cell cholesterol levels impair insulin secretion and reduce plasma insulin levels. This study establishes that low plasma insulin levels have a detrimental effect on two major insulin target tissues: adipose tissue and skeletal muscle. Mice with increased β-cell cholesterol lev...

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Detalles Bibliográficos
Autores principales: Cochran, Blake J., Hou, Liming, Manavalan, Anil Paul Chirackal, Moore, Benjamin M., Tabet, Fatiha, Sultana, Afroza, Cuesta Torres, Luisa, Tang, Shudi, Shrestha, Sudichhya, Senanayake, Praween, Patel, Mili, Ryder, William J., Bongers, Andre, Maraninchi, Marie, Wasinger, Valerie C., Westerterp, Marit, Tall, Alan R., Barter, Philip J., Rye, Kerry-Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132410/
https://www.ncbi.nlm.nih.gov/pubmed/27702832
http://dx.doi.org/10.2337/db16-0668

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