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Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age
BACKGROUND: Prenatal exposure to endocrine disruptors has been associated with increased risk of childhood obesity. However, epidemiologic studies on polybrominated diphenyl ethers (PBDEs) are limited despite animal studies indicating PBDEs’ potential role as an obesogen. OBJECTIVES: We investigated...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132628/ https://www.ncbi.nlm.nih.gov/pubmed/27285825 http://dx.doi.org/10.1289/EHP139 |
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author | Vuong, Ann M. Braun, Joseph M. Sjödin, Andreas Webster, Glenys M. Yolton, Kimberly Lanphear, Bruce P. Chen, Aimin |
author_facet | Vuong, Ann M. Braun, Joseph M. Sjödin, Andreas Webster, Glenys M. Yolton, Kimberly Lanphear, Bruce P. Chen, Aimin |
author_sort | Vuong, Ann M. |
collection | PubMed |
description | BACKGROUND: Prenatal exposure to endocrine disruptors has been associated with increased risk of childhood obesity. However, epidemiologic studies on polybrominated diphenyl ethers (PBDEs) are limited despite animal studies indicating PBDEs’ potential role as an obesogen. OBJECTIVES: We investigated whether maternal concentrations of BDEs 28, 47, 99, 100, 153, and ΣPBDEs during pregnancy were associated with anthropometric measures in children aged 1–8 years. METHODS: We examined 318 mother–child pairs in the Health Outcomes and Measures of the Environment (HOME) Study, a birth cohort enrolled from 2003 through 2006 (Cincinnati, OH). Serum PBDEs were measured at 16 ± 3 weeks gestation. We measured child height (1–8 years), weight (1–8 years), body mass index (BMI) (2–8 years), waist circumference (4–8 years), and body fat (8 years). To account for repeated measures, we used linear mixed models and generalized estimating equations to estimate associations between maternal PBDEs and child anthropometric measures. RESULTS: We found no statistically significant associations between prenatal PBDEs and height or weight z-score. A 10-fold increase in maternal serum BDE-153 was associated with lower BMI z-score (β = –0.36; 95% CI: –0.60, –0.13) at 2–8 years, smaller waist circumference (β = –1.81 cm; 95% CI: –3.13, –0.50) at 4–8 years, and lower percent body fat (β = –2.37%; 95% CI: –4.21, –0.53) at 8 years. A decrease in waist circumference at 4–8 years was observed with a 10-fold increase in BDE-100 (β = –1.50 cm; 95% CI: –2.93, –0.08) and ΣPBDEs (β = –1.57 cm; 95% CI: –3.11, –0.02). CONCLUSIONS: Reverse causality may have resulted in prenatal PBDEs, particularly BDE-153, and decreased BMI, waist circumference, and body fat. CITATION: Vuong AM, Braun JM, Sjödin A, Webster GM, Yolton K, Lanphear BP, Chen A. 2016. Prenatal polybrominated diphenyl ether exposure and body mass index in children up to 8 years of age. Environ Health Perspect 124:1891–1897; http://dx.doi.org/10.1289/EHP139 |
format | Online Article Text |
id | pubmed-5132628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-51326282016-12-12 Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age Vuong, Ann M. Braun, Joseph M. Sjödin, Andreas Webster, Glenys M. Yolton, Kimberly Lanphear, Bruce P. Chen, Aimin Environ Health Perspect Research BACKGROUND: Prenatal exposure to endocrine disruptors has been associated with increased risk of childhood obesity. However, epidemiologic studies on polybrominated diphenyl ethers (PBDEs) are limited despite animal studies indicating PBDEs’ potential role as an obesogen. OBJECTIVES: We investigated whether maternal concentrations of BDEs 28, 47, 99, 100, 153, and ΣPBDEs during pregnancy were associated with anthropometric measures in children aged 1–8 years. METHODS: We examined 318 mother–child pairs in the Health Outcomes and Measures of the Environment (HOME) Study, a birth cohort enrolled from 2003 through 2006 (Cincinnati, OH). Serum PBDEs were measured at 16 ± 3 weeks gestation. We measured child height (1–8 years), weight (1–8 years), body mass index (BMI) (2–8 years), waist circumference (4–8 years), and body fat (8 years). To account for repeated measures, we used linear mixed models and generalized estimating equations to estimate associations between maternal PBDEs and child anthropometric measures. RESULTS: We found no statistically significant associations between prenatal PBDEs and height or weight z-score. A 10-fold increase in maternal serum BDE-153 was associated with lower BMI z-score (β = –0.36; 95% CI: –0.60, –0.13) at 2–8 years, smaller waist circumference (β = –1.81 cm; 95% CI: –3.13, –0.50) at 4–8 years, and lower percent body fat (β = –2.37%; 95% CI: –4.21, –0.53) at 8 years. A decrease in waist circumference at 4–8 years was observed with a 10-fold increase in BDE-100 (β = –1.50 cm; 95% CI: –2.93, –0.08) and ΣPBDEs (β = –1.57 cm; 95% CI: –3.11, –0.02). CONCLUSIONS: Reverse causality may have resulted in prenatal PBDEs, particularly BDE-153, and decreased BMI, waist circumference, and body fat. CITATION: Vuong AM, Braun JM, Sjödin A, Webster GM, Yolton K, Lanphear BP, Chen A. 2016. Prenatal polybrominated diphenyl ether exposure and body mass index in children up to 8 years of age. Environ Health Perspect 124:1891–1897; http://dx.doi.org/10.1289/EHP139 National Institute of Environmental Health Sciences 2016-06-10 2016-12 /pmc/articles/PMC5132628/ /pubmed/27285825 http://dx.doi.org/10.1289/EHP139 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Vuong, Ann M. Braun, Joseph M. Sjödin, Andreas Webster, Glenys M. Yolton, Kimberly Lanphear, Bruce P. Chen, Aimin Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age |
title | Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age |
title_full | Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age |
title_fullStr | Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age |
title_full_unstemmed | Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age |
title_short | Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age |
title_sort | prenatal polybrominated diphenyl ether exposure and body mass index in children up to 8 years of age |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132628/ https://www.ncbi.nlm.nih.gov/pubmed/27285825 http://dx.doi.org/10.1289/EHP139 |
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