Cargando…
Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial
Background: Probiotic supplementation to women during pregnancy and lactation can modulate breast milk composition, with immune benefits being transferred to their infants. Aim: The aim of the study was to evaluate the effect of high-dose probiotic supplementation to women during late pregnancy and...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133065/ https://www.ncbi.nlm.nih.gov/pubmed/27801789 http://dx.doi.org/10.3390/nu8110677 |
_version_ | 1782471201589821440 |
---|---|
author | Baldassarre, Maria Elisabetta Di Mauro, Antonio Mastromarino, Paola Fanelli, Margherita Martinelli, Domenico Urbano, Flavia Capobianco, Daniela Laforgia, Nicola |
author_facet | Baldassarre, Maria Elisabetta Di Mauro, Antonio Mastromarino, Paola Fanelli, Margherita Martinelli, Domenico Urbano, Flavia Capobianco, Daniela Laforgia, Nicola |
author_sort | Baldassarre, Maria Elisabetta |
collection | PubMed |
description | Background: Probiotic supplementation to women during pregnancy and lactation can modulate breast milk composition, with immune benefits being transferred to their infants. Aim: The aim of the study was to evaluate the effect of high-dose probiotic supplementation to women during late pregnancy and lactation on cytokine profile and secretory IgA (sIgA) in breast milk and thus to study if differences in breast milk composition can affect lactoferrin and sIgA levels in stool samples of newborns. The safety of maternal probiotic administration on neonatal growth pattern and gastrointestinal symptoms were also evaluated. Methods: In a double-blind, placebo-controlled, randomized trial, 66 women took either the probiotic (n = 33) or a placebo (n = 33) daily. Levels of interleukins (IL-6, IL-10 and IL-1β), transforming growth factor-β1 (TGF-β1), and sIgA in breast milk; and the level of sIgA and lactoferrin in newborn stool samples were analyzed at birth and then again at one month of life. Antropometrical evaluation and analysis of gastrointestinal events in newborns was also performed. Results: Probiotic maternal consumption had a significant impact on IL6 mean values in colostrum and on IL10 and TGF-β1 mean values in mature breast milk. Fecal sIgA mean values were higher in newborns whose mothers took the probiotic product than in the control group. Probiotic maternal supplementation seems to decrease incidence of infantile colic and regurgitation in infants. Conclusion: High-dose multi-strain probiotic administration to women during pregnancy influences breast milk cytokines pattern and sIgA production in newborns, and seems to improve gastrointestinal functional symptoms in infants. |
format | Online Article Text |
id | pubmed-5133065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51330652016-12-11 Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial Baldassarre, Maria Elisabetta Di Mauro, Antonio Mastromarino, Paola Fanelli, Margherita Martinelli, Domenico Urbano, Flavia Capobianco, Daniela Laforgia, Nicola Nutrients Article Background: Probiotic supplementation to women during pregnancy and lactation can modulate breast milk composition, with immune benefits being transferred to their infants. Aim: The aim of the study was to evaluate the effect of high-dose probiotic supplementation to women during late pregnancy and lactation on cytokine profile and secretory IgA (sIgA) in breast milk and thus to study if differences in breast milk composition can affect lactoferrin and sIgA levels in stool samples of newborns. The safety of maternal probiotic administration on neonatal growth pattern and gastrointestinal symptoms were also evaluated. Methods: In a double-blind, placebo-controlled, randomized trial, 66 women took either the probiotic (n = 33) or a placebo (n = 33) daily. Levels of interleukins (IL-6, IL-10 and IL-1β), transforming growth factor-β1 (TGF-β1), and sIgA in breast milk; and the level of sIgA and lactoferrin in newborn stool samples were analyzed at birth and then again at one month of life. Antropometrical evaluation and analysis of gastrointestinal events in newborns was also performed. Results: Probiotic maternal consumption had a significant impact on IL6 mean values in colostrum and on IL10 and TGF-β1 mean values in mature breast milk. Fecal sIgA mean values were higher in newborns whose mothers took the probiotic product than in the control group. Probiotic maternal supplementation seems to decrease incidence of infantile colic and regurgitation in infants. Conclusion: High-dose multi-strain probiotic administration to women during pregnancy influences breast milk cytokines pattern and sIgA production in newborns, and seems to improve gastrointestinal functional symptoms in infants. MDPI 2016-10-27 /pmc/articles/PMC5133065/ /pubmed/27801789 http://dx.doi.org/10.3390/nu8110677 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Baldassarre, Maria Elisabetta Di Mauro, Antonio Mastromarino, Paola Fanelli, Margherita Martinelli, Domenico Urbano, Flavia Capobianco, Daniela Laforgia, Nicola Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial |
title | Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial |
title_full | Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial |
title_fullStr | Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial |
title_full_unstemmed | Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial |
title_short | Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial |
title_sort | administration of a multi-strain probiotic product to women in the perinatal period differentially affects the breast milk cytokine profile and may have beneficial effects on neonatal gastrointestinal functional symptoms. a randomized clinical trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133065/ https://www.ncbi.nlm.nih.gov/pubmed/27801789 http://dx.doi.org/10.3390/nu8110677 |
work_keys_str_mv | AT baldassarremariaelisabetta administrationofamultistrainprobioticproducttowomenintheperinatalperioddifferentiallyaffectsthebreastmilkcytokineprofileandmayhavebeneficialeffectsonneonatalgastrointestinalfunctionalsymptomsarandomizedclinicaltrial AT dimauroantonio administrationofamultistrainprobioticproducttowomenintheperinatalperioddifferentiallyaffectsthebreastmilkcytokineprofileandmayhavebeneficialeffectsonneonatalgastrointestinalfunctionalsymptomsarandomizedclinicaltrial AT mastromarinopaola administrationofamultistrainprobioticproducttowomenintheperinatalperioddifferentiallyaffectsthebreastmilkcytokineprofileandmayhavebeneficialeffectsonneonatalgastrointestinalfunctionalsymptomsarandomizedclinicaltrial AT fanellimargherita administrationofamultistrainprobioticproducttowomenintheperinatalperioddifferentiallyaffectsthebreastmilkcytokineprofileandmayhavebeneficialeffectsonneonatalgastrointestinalfunctionalsymptomsarandomizedclinicaltrial AT martinellidomenico administrationofamultistrainprobioticproducttowomenintheperinatalperioddifferentiallyaffectsthebreastmilkcytokineprofileandmayhavebeneficialeffectsonneonatalgastrointestinalfunctionalsymptomsarandomizedclinicaltrial AT urbanoflavia administrationofamultistrainprobioticproducttowomenintheperinatalperioddifferentiallyaffectsthebreastmilkcytokineprofileandmayhavebeneficialeffectsonneonatalgastrointestinalfunctionalsymptomsarandomizedclinicaltrial AT capobiancodaniela administrationofamultistrainprobioticproducttowomenintheperinatalperioddifferentiallyaffectsthebreastmilkcytokineprofileandmayhavebeneficialeffectsonneonatalgastrointestinalfunctionalsymptomsarandomizedclinicaltrial AT laforgianicola administrationofamultistrainprobioticproducttowomenintheperinatalperioddifferentiallyaffectsthebreastmilkcytokineprofileandmayhavebeneficialeffectsonneonatalgastrointestinalfunctionalsymptomsarandomizedclinicaltrial |