Cargando…

The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program

The hypothesized effect of vitamin D on C-reactive protein (CRP) has received substantial attention as a potential means to alleviate the risk for cardiovascular disease. However, observational studies have been inconsistent in their reporting of associations between serum 25-hydroxyvitamin D (25(OH...

Descripción completa

Detalles Bibliográficos
Autores principales: Mastroeni, Silmara S. B. S., Munasinghe, Lalani L., Pham, Truong-Minh, Loehr, Sarah A., Ekwaru, John Paul, Mastroeni, Marco F., Veugelers, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133083/
https://www.ncbi.nlm.nih.gov/pubmed/27827910
http://dx.doi.org/10.3390/nu8110696
_version_ 1782471205750571008
author Mastroeni, Silmara S. B. S.
Munasinghe, Lalani L.
Pham, Truong-Minh
Loehr, Sarah A.
Ekwaru, John Paul
Mastroeni, Marco F.
Veugelers, Paul J.
author_facet Mastroeni, Silmara S. B. S.
Munasinghe, Lalani L.
Pham, Truong-Minh
Loehr, Sarah A.
Ekwaru, John Paul
Mastroeni, Marco F.
Veugelers, Paul J.
author_sort Mastroeni, Silmara S. B. S.
collection PubMed
description The hypothesized effect of vitamin D on C-reactive protein (CRP) has received substantial attention as a potential means to alleviate the risk for cardiovascular disease. However, observational studies have been inconsistent in their reporting of associations between serum 25-hydroxyvitamin D (25(OH)D) and CRP concentrations, and trials and meta analyses have been inconsistent in their conclusions regarding the effect of vitamin D supplementation on CRP concentrations. These supplementation trials were mostly conducted among patients with more or less inflammatory complications and did not consider potential distinctive effects by weight status. To further our understanding of the potential influences of vitamin D on CRP, we analyzed longitudinal observations of 6755 participants of a preventative health program. On average, serum 25(OH)D concentrations increased from 88.3 to 121.0 nmol/L and those of CRP decreased from 1.7 to 1.6 mg/L between baseline and follow up. Relative to obese participants without temporal increases in 25(OH)D, those who showed improvements of <25, 25–50, 50–75, and more than 75 nmol/L at follow up were 0.57 (95% confidence interval: 0.37–0.88), 0.54 (0.34–0.85), 0.49 (0.30–0.80), and 0.48 (0.29–0.78) times as likely to have elevated CRP concentrations (≥1 mg/L), respectively. These associations were less pronounced and not statistically significant for normal weight and overweight participants. Herewith, the findings suggest that promotion of adequate serum 25(OH)D concentrations among obese individuals along with healthy lifestyles may alleviate the public health burden associated with cardiovascular disease.
format Online
Article
Text
id pubmed-5133083
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-51330832016-12-11 The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program Mastroeni, Silmara S. B. S. Munasinghe, Lalani L. Pham, Truong-Minh Loehr, Sarah A. Ekwaru, John Paul Mastroeni, Marco F. Veugelers, Paul J. Nutrients Article The hypothesized effect of vitamin D on C-reactive protein (CRP) has received substantial attention as a potential means to alleviate the risk for cardiovascular disease. However, observational studies have been inconsistent in their reporting of associations between serum 25-hydroxyvitamin D (25(OH)D) and CRP concentrations, and trials and meta analyses have been inconsistent in their conclusions regarding the effect of vitamin D supplementation on CRP concentrations. These supplementation trials were mostly conducted among patients with more or less inflammatory complications and did not consider potential distinctive effects by weight status. To further our understanding of the potential influences of vitamin D on CRP, we analyzed longitudinal observations of 6755 participants of a preventative health program. On average, serum 25(OH)D concentrations increased from 88.3 to 121.0 nmol/L and those of CRP decreased from 1.7 to 1.6 mg/L between baseline and follow up. Relative to obese participants without temporal increases in 25(OH)D, those who showed improvements of <25, 25–50, 50–75, and more than 75 nmol/L at follow up were 0.57 (95% confidence interval: 0.37–0.88), 0.54 (0.34–0.85), 0.49 (0.30–0.80), and 0.48 (0.29–0.78) times as likely to have elevated CRP concentrations (≥1 mg/L), respectively. These associations were less pronounced and not statistically significant for normal weight and overweight participants. Herewith, the findings suggest that promotion of adequate serum 25(OH)D concentrations among obese individuals along with healthy lifestyles may alleviate the public health burden associated with cardiovascular disease. MDPI 2016-11-04 /pmc/articles/PMC5133083/ /pubmed/27827910 http://dx.doi.org/10.3390/nu8110696 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mastroeni, Silmara S. B. S.
Munasinghe, Lalani L.
Pham, Truong-Minh
Loehr, Sarah A.
Ekwaru, John Paul
Mastroeni, Marco F.
Veugelers, Paul J.
The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program
title The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program
title_full The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program
title_fullStr The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program
title_full_unstemmed The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program
title_short The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program
title_sort effect of serum 25-hydroxyvitamin d concentrations on elevated serum c-reactive protein concentrations in normal weight, overweight and obese participants of a preventive health program
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133083/
https://www.ncbi.nlm.nih.gov/pubmed/27827910
http://dx.doi.org/10.3390/nu8110696
work_keys_str_mv AT mastroenisilmarasbs theeffectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT munasinghelalanil theeffectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT phamtruongminh theeffectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT loehrsaraha theeffectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT ekwarujohnpaul theeffectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT mastroenimarcof theeffectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT veugelerspaulj theeffectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT mastroenisilmarasbs effectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT munasinghelalanil effectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT phamtruongminh effectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT loehrsaraha effectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT ekwarujohnpaul effectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT mastroenimarcof effectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram
AT veugelerspaulj effectofserum25hydroxyvitamindconcentrationsonelevatedserumcreactiveproteinconcentrationsinnormalweightoverweightandobeseparticipantsofapreventivehealthprogram