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Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults
We aimed to investigate associations of the dietary inflammatory index (DII) with glucose-insulin homeostasis markers, and the risk of glucose intolerance. This cross-sectional study included 2975 adults from the Tehran Lipid and Glucose Study. Fasting plasma glucose (FPG), 2-h post-load glucose (2h...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133119/ https://www.ncbi.nlm.nih.gov/pubmed/27869717 http://dx.doi.org/10.3390/nu8110735 |
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author | Moslehi, Nazanin Ehsani, Behnaz Mirmiran, Parvin Shivappa, Nitin Tohidi, Maryam Hébert, James R. Azizi, Fereidoun |
author_facet | Moslehi, Nazanin Ehsani, Behnaz Mirmiran, Parvin Shivappa, Nitin Tohidi, Maryam Hébert, James R. Azizi, Fereidoun |
author_sort | Moslehi, Nazanin |
collection | PubMed |
description | We aimed to investigate associations of the dietary inflammatory index (DII) with glucose-insulin homeostasis markers, and the risk of glucose intolerance. This cross-sectional study included 2975 adults from the Tehran Lipid and Glucose Study. Fasting plasma glucose (FPG), 2-h post-load glucose (2h-PG), and fasting serum insulin were measured. Homeostatic model assessment of insulin resistance index (HOMA-IR) and β-cell function (HOMA-B), and the quantitative insulin sensitivity check index (QUICKI) were calculated. Glucose tolerance abnormalities included impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2DM). DII scores were positively associated with 2h-PG (β = 0.04; p = 0.05). There was no significant linear trend across quartiles of DII for adjusted means of glucose-insulin homeostasis markers. Participants in the highest quartile of DII score tended to have higher FPG compared to those in the second quartile of DII score (5.46 vs. 5.38 mmol/L, p = 0.07) and higher fasting insulin and HOMA-IR compared to those in the lowest quartile (8.52 vs. 8.12 µU/mL for fasting insulin, p = 0.07; 2.06 vs. 1.96 for HOMA-IR, p = 0.08). No significant associations were observed between DII and risk of IFG, IGT, T2DM, and insulin resistance. Among glucose-insulin homeostasis markers, DII had a positive weak association only with 2h-PG. |
format | Online Article Text |
id | pubmed-5133119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51331192016-12-11 Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults Moslehi, Nazanin Ehsani, Behnaz Mirmiran, Parvin Shivappa, Nitin Tohidi, Maryam Hébert, James R. Azizi, Fereidoun Nutrients Article We aimed to investigate associations of the dietary inflammatory index (DII) with glucose-insulin homeostasis markers, and the risk of glucose intolerance. This cross-sectional study included 2975 adults from the Tehran Lipid and Glucose Study. Fasting plasma glucose (FPG), 2-h post-load glucose (2h-PG), and fasting serum insulin were measured. Homeostatic model assessment of insulin resistance index (HOMA-IR) and β-cell function (HOMA-B), and the quantitative insulin sensitivity check index (QUICKI) were calculated. Glucose tolerance abnormalities included impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2DM). DII scores were positively associated with 2h-PG (β = 0.04; p = 0.05). There was no significant linear trend across quartiles of DII for adjusted means of glucose-insulin homeostasis markers. Participants in the highest quartile of DII score tended to have higher FPG compared to those in the second quartile of DII score (5.46 vs. 5.38 mmol/L, p = 0.07) and higher fasting insulin and HOMA-IR compared to those in the lowest quartile (8.52 vs. 8.12 µU/mL for fasting insulin, p = 0.07; 2.06 vs. 1.96 for HOMA-IR, p = 0.08). No significant associations were observed between DII and risk of IFG, IGT, T2DM, and insulin resistance. Among glucose-insulin homeostasis markers, DII had a positive weak association only with 2h-PG. MDPI 2016-11-18 /pmc/articles/PMC5133119/ /pubmed/27869717 http://dx.doi.org/10.3390/nu8110735 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moslehi, Nazanin Ehsani, Behnaz Mirmiran, Parvin Shivappa, Nitin Tohidi, Maryam Hébert, James R. Azizi, Fereidoun Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults |
title | Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults |
title_full | Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults |
title_fullStr | Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults |
title_full_unstemmed | Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults |
title_short | Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults |
title_sort | inflammatory properties of diet and glucose-insulin homeostasis in a cohort of iranian adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133119/ https://www.ncbi.nlm.nih.gov/pubmed/27869717 http://dx.doi.org/10.3390/nu8110735 |
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