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Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults

We aimed to investigate associations of the dietary inflammatory index (DII) with glucose-insulin homeostasis markers, and the risk of glucose intolerance. This cross-sectional study included 2975 adults from the Tehran Lipid and Glucose Study. Fasting plasma glucose (FPG), 2-h post-load glucose (2h...

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Autores principales: Moslehi, Nazanin, Ehsani, Behnaz, Mirmiran, Parvin, Shivappa, Nitin, Tohidi, Maryam, Hébert, James R., Azizi, Fereidoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133119/
https://www.ncbi.nlm.nih.gov/pubmed/27869717
http://dx.doi.org/10.3390/nu8110735
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author Moslehi, Nazanin
Ehsani, Behnaz
Mirmiran, Parvin
Shivappa, Nitin
Tohidi, Maryam
Hébert, James R.
Azizi, Fereidoun
author_facet Moslehi, Nazanin
Ehsani, Behnaz
Mirmiran, Parvin
Shivappa, Nitin
Tohidi, Maryam
Hébert, James R.
Azizi, Fereidoun
author_sort Moslehi, Nazanin
collection PubMed
description We aimed to investigate associations of the dietary inflammatory index (DII) with glucose-insulin homeostasis markers, and the risk of glucose intolerance. This cross-sectional study included 2975 adults from the Tehran Lipid and Glucose Study. Fasting plasma glucose (FPG), 2-h post-load glucose (2h-PG), and fasting serum insulin were measured. Homeostatic model assessment of insulin resistance index (HOMA-IR) and β-cell function (HOMA-B), and the quantitative insulin sensitivity check index (QUICKI) were calculated. Glucose tolerance abnormalities included impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2DM). DII scores were positively associated with 2h-PG (β = 0.04; p = 0.05). There was no significant linear trend across quartiles of DII for adjusted means of glucose-insulin homeostasis markers. Participants in the highest quartile of DII score tended to have higher FPG compared to those in the second quartile of DII score (5.46 vs. 5.38 mmol/L, p = 0.07) and higher fasting insulin and HOMA-IR compared to those in the lowest quartile (8.52 vs. 8.12 µU/mL for fasting insulin, p = 0.07; 2.06 vs. 1.96 for HOMA-IR, p = 0.08). No significant associations were observed between DII and risk of IFG, IGT, T2DM, and insulin resistance. Among glucose-insulin homeostasis markers, DII had a positive weak association only with 2h-PG.
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spelling pubmed-51331192016-12-11 Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults Moslehi, Nazanin Ehsani, Behnaz Mirmiran, Parvin Shivappa, Nitin Tohidi, Maryam Hébert, James R. Azizi, Fereidoun Nutrients Article We aimed to investigate associations of the dietary inflammatory index (DII) with glucose-insulin homeostasis markers, and the risk of glucose intolerance. This cross-sectional study included 2975 adults from the Tehran Lipid and Glucose Study. Fasting plasma glucose (FPG), 2-h post-load glucose (2h-PG), and fasting serum insulin were measured. Homeostatic model assessment of insulin resistance index (HOMA-IR) and β-cell function (HOMA-B), and the quantitative insulin sensitivity check index (QUICKI) were calculated. Glucose tolerance abnormalities included impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2DM). DII scores were positively associated with 2h-PG (β = 0.04; p = 0.05). There was no significant linear trend across quartiles of DII for adjusted means of glucose-insulin homeostasis markers. Participants in the highest quartile of DII score tended to have higher FPG compared to those in the second quartile of DII score (5.46 vs. 5.38 mmol/L, p = 0.07) and higher fasting insulin and HOMA-IR compared to those in the lowest quartile (8.52 vs. 8.12 µU/mL for fasting insulin, p = 0.07; 2.06 vs. 1.96 for HOMA-IR, p = 0.08). No significant associations were observed between DII and risk of IFG, IGT, T2DM, and insulin resistance. Among glucose-insulin homeostasis markers, DII had a positive weak association only with 2h-PG. MDPI 2016-11-18 /pmc/articles/PMC5133119/ /pubmed/27869717 http://dx.doi.org/10.3390/nu8110735 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moslehi, Nazanin
Ehsani, Behnaz
Mirmiran, Parvin
Shivappa, Nitin
Tohidi, Maryam
Hébert, James R.
Azizi, Fereidoun
Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults
title Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults
title_full Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults
title_fullStr Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults
title_full_unstemmed Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults
title_short Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults
title_sort inflammatory properties of diet and glucose-insulin homeostasis in a cohort of iranian adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133119/
https://www.ncbi.nlm.nih.gov/pubmed/27869717
http://dx.doi.org/10.3390/nu8110735
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