Topical Application of Apricot Kernel Extract Improves Dry Eye Symptoms in a Unilateral Exorbital Lacrimal Gland Excision Mouse

The purpose of this study was to investigate the therapeutic effects of topical application of apricot kernel extract (AKE) in a unilateral exorbital lacrimal gland excision mouse model of experimental dry eye. Dry eye was induced by surgical removal of the lacrimal gland. Eye drops containing 0.5 o...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Chan-Sik, Jo, Kyuhyung, Lee, Ik-Soo, Kim, Junghyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133132/
https://www.ncbi.nlm.nih.gov/pubmed/27886047
http://dx.doi.org/10.3390/nu8110750
_version_ 1782471216854990848
author Kim, Chan-Sik
Jo, Kyuhyung
Lee, Ik-Soo
Kim, Junghyun
author_facet Kim, Chan-Sik
Jo, Kyuhyung
Lee, Ik-Soo
Kim, Junghyun
author_sort Kim, Chan-Sik
collection PubMed
description The purpose of this study was to investigate the therapeutic effects of topical application of apricot kernel extract (AKE) in a unilateral exorbital lacrimal gland excision mouse model of experimental dry eye. Dry eye was induced by surgical removal of the lacrimal gland. Eye drops containing 0.5 or 1 mg/mL AKE were administered twice a day from day 3 to day 7 after surgery. Tear fluid volume and corneal irregularity scores were determined. In addition, we examined the immunohistochemical expression level of Muc4. The topical administration of AKE dose-dependently improved all clinical dry eye symptoms by promoting the secretion of tear fluid and mucin. Thus, the results of this study indicate that AKE may be an efficacious topical agent for treating dry eye disease.
format Online
Article
Text
id pubmed-5133132
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-51331322016-12-11 Topical Application of Apricot Kernel Extract Improves Dry Eye Symptoms in a Unilateral Exorbital Lacrimal Gland Excision Mouse Kim, Chan-Sik Jo, Kyuhyung Lee, Ik-Soo Kim, Junghyun Nutrients Article The purpose of this study was to investigate the therapeutic effects of topical application of apricot kernel extract (AKE) in a unilateral exorbital lacrimal gland excision mouse model of experimental dry eye. Dry eye was induced by surgical removal of the lacrimal gland. Eye drops containing 0.5 or 1 mg/mL AKE were administered twice a day from day 3 to day 7 after surgery. Tear fluid volume and corneal irregularity scores were determined. In addition, we examined the immunohistochemical expression level of Muc4. The topical administration of AKE dose-dependently improved all clinical dry eye symptoms by promoting the secretion of tear fluid and mucin. Thus, the results of this study indicate that AKE may be an efficacious topical agent for treating dry eye disease. MDPI 2016-11-23 /pmc/articles/PMC5133132/ /pubmed/27886047 http://dx.doi.org/10.3390/nu8110750 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Chan-Sik
Jo, Kyuhyung
Lee, Ik-Soo
Kim, Junghyun
Topical Application of Apricot Kernel Extract Improves Dry Eye Symptoms in a Unilateral Exorbital Lacrimal Gland Excision Mouse
title Topical Application of Apricot Kernel Extract Improves Dry Eye Symptoms in a Unilateral Exorbital Lacrimal Gland Excision Mouse
title_full Topical Application of Apricot Kernel Extract Improves Dry Eye Symptoms in a Unilateral Exorbital Lacrimal Gland Excision Mouse
title_fullStr Topical Application of Apricot Kernel Extract Improves Dry Eye Symptoms in a Unilateral Exorbital Lacrimal Gland Excision Mouse
title_full_unstemmed Topical Application of Apricot Kernel Extract Improves Dry Eye Symptoms in a Unilateral Exorbital Lacrimal Gland Excision Mouse
title_short Topical Application of Apricot Kernel Extract Improves Dry Eye Symptoms in a Unilateral Exorbital Lacrimal Gland Excision Mouse
title_sort topical application of apricot kernel extract improves dry eye symptoms in a unilateral exorbital lacrimal gland excision mouse
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133132/
https://www.ncbi.nlm.nih.gov/pubmed/27886047
http://dx.doi.org/10.3390/nu8110750
work_keys_str_mv AT kimchansik topicalapplicationofapricotkernelextractimprovesdryeyesymptomsinaunilateralexorbitallacrimalglandexcisionmouse
AT jokyuhyung topicalapplicationofapricotkernelextractimprovesdryeyesymptomsinaunilateralexorbitallacrimalglandexcisionmouse
AT leeiksoo topicalapplicationofapricotkernelextractimprovesdryeyesymptomsinaunilateralexorbitallacrimalglandexcisionmouse
AT kimjunghyun topicalapplicationofapricotkernelextractimprovesdryeyesymptomsinaunilateralexorbitallacrimalglandexcisionmouse

Ejemplares similares