Reversible lysine-specific demethylase 1 antagonist HCI-2509 inhibits growth and decreases c-MYC in castration- and docetaxel-resistant prostate cancer cells

BACKGROUND: Lysine-specific demethylase 1 (LSD1 or KDM1A) overexpression correlates with poor survival and castration resistance in prostate cancer. LSD1 is a coregulator of ligand-independent androgen receptor signaling promoting c-MYC expression. We examined the antitumor efficacy of LSD1 inhibiti...

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Detalles Bibliográficos
Autores principales: Gupta, S, Weston, A, Bearrs, J, Thode, T, Neiss, A, Soldi, R, Sharma, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133270/
https://www.ncbi.nlm.nih.gov/pubmed/27349498
http://dx.doi.org/10.1038/pcan.2016.21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133270/
https://www.ncbi.nlm.nih.gov/pubmed/27349498
http://dx.doi.org/10.1038/pcan.2016.21

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