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Genetics of inherited cardiocutaneous syndromes: a review
The life of a human being originates as a single cell which, under the influence of certain factors, divides sequentially into multiple cells that subsequently become committed to develop and differentiate into the different structures and organs. Alterations occurring early on in the development pr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133403/ https://www.ncbi.nlm.nih.gov/pubmed/27933191 http://dx.doi.org/10.1136/openhrt-2016-000442 |
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author | Bardawil, Tara Khalil, Samar Bergqvist, Christina Abbas, Ossama Kibbi, Abdul Ghani Bitar, Fadi Nemer, Georges Kurban, Mazen |
author_facet | Bardawil, Tara Khalil, Samar Bergqvist, Christina Abbas, Ossama Kibbi, Abdul Ghani Bitar, Fadi Nemer, Georges Kurban, Mazen |
author_sort | Bardawil, Tara |
collection | PubMed |
description | The life of a human being originates as a single cell which, under the influence of certain factors, divides sequentially into multiple cells that subsequently become committed to develop and differentiate into the different structures and organs. Alterations occurring early on in the development process may lead to fetal demise in utero. Conversely, abnormalities at later stages may result in structural and/or functional abnormalities of varying severities. The cardiovascular system and skin share certain developmental and structural factors; therefore, it is not surprising to find several inherited syndromes with both cardiac and skin manifestations. Here, we will review the overlapping pathways in the development of the skin and heart, as well as the resulting syndromes. We will also highlight several cutaneous clues that may help physicians screen and uncover cardiac anomalies that may be otherwise hidden and result in sudden cardiac death. |
format | Online Article Text |
id | pubmed-5133403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51334032016-12-08 Genetics of inherited cardiocutaneous syndromes: a review Bardawil, Tara Khalil, Samar Bergqvist, Christina Abbas, Ossama Kibbi, Abdul Ghani Bitar, Fadi Nemer, Georges Kurban, Mazen Open Heart Special Populations The life of a human being originates as a single cell which, under the influence of certain factors, divides sequentially into multiple cells that subsequently become committed to develop and differentiate into the different structures and organs. Alterations occurring early on in the development process may lead to fetal demise in utero. Conversely, abnormalities at later stages may result in structural and/or functional abnormalities of varying severities. The cardiovascular system and skin share certain developmental and structural factors; therefore, it is not surprising to find several inherited syndromes with both cardiac and skin manifestations. Here, we will review the overlapping pathways in the development of the skin and heart, as well as the resulting syndromes. We will also highlight several cutaneous clues that may help physicians screen and uncover cardiac anomalies that may be otherwise hidden and result in sudden cardiac death. BMJ Publishing Group 2016-11-22 /pmc/articles/PMC5133403/ /pubmed/27933191 http://dx.doi.org/10.1136/openhrt-2016-000442 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Special Populations Bardawil, Tara Khalil, Samar Bergqvist, Christina Abbas, Ossama Kibbi, Abdul Ghani Bitar, Fadi Nemer, Georges Kurban, Mazen Genetics of inherited cardiocutaneous syndromes: a review |
title | Genetics of inherited cardiocutaneous syndromes: a review |
title_full | Genetics of inherited cardiocutaneous syndromes: a review |
title_fullStr | Genetics of inherited cardiocutaneous syndromes: a review |
title_full_unstemmed | Genetics of inherited cardiocutaneous syndromes: a review |
title_short | Genetics of inherited cardiocutaneous syndromes: a review |
title_sort | genetics of inherited cardiocutaneous syndromes: a review |
topic | Special Populations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133403/ https://www.ncbi.nlm.nih.gov/pubmed/27933191 http://dx.doi.org/10.1136/openhrt-2016-000442 |
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