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Spontaneous destructive periodontitis and skeletal bone damage in transgenic mice carrying a human shared epitope-coding HLA-DRB1 allele

OBJECTIVE: Shared epitope (SE)-coding DRB1 alleles are associated with bone erosion in several diseases, including rheumatoid arthritis (RA) and periodontal disease (PD), but the underlying mechanism is unknown. We have recently identified the SE as an osteoclast-activating ligand. To better underst...

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Detalles Bibliográficos
Autores principales:	Gehlot, Prashasnika, Volk, Sarah L, Rios, Hector F, Jepsen, Karl J, Holoshitz, Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Animal Models
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133411/ https://www.ncbi.nlm.nih.gov/pubmed/27933212 http://dx.doi.org/10.1136/rmdopen-2016-000349

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