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A novel statistical method for rare-variant association studies in general pedigrees

Both population-based and family-based designs are commonly used in genetic association studies to identify rare variants that underlie complex diseases. For any type of study design, the statistical power will be improved if rare variants can be enriched in the samples. Family-based designs, with a...

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Detalles Bibliográficos
Autores principales:	Zhu, Huanhuan, Wang, Zhenchuan, Wang, Xuexia, Sha, Qiuying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133499/ https://www.ncbi.nlm.nih.gov/pubmed/27980635 http://dx.doi.org/10.1186/s12919-016-0029-6

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