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A general method for combining different family-based rare-variant tests of association to improve power and robustness of a wide range of genetic architectures

Current rare-variant, gene-based tests of association often suffer from a lack of statistical power to detect genotype–phenotype associations as a result of a lack of prior knowledge of genetic disease models combined with limited observations of extremely rare causal variants in population-based sa...

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Detalles Bibliográficos
Autores principales: Green, Alden, Cook, Kaitlyn, Grinde, Kelsey, Valcarcel, Alessandra, Tintle, Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133502/
https://www.ncbi.nlm.nih.gov/pubmed/27980630
http://dx.doi.org/10.1186/s12919-016-0024-y