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A general method for combining different family-based rare-variant tests of association to improve power and robustness of a wide range of genetic architectures
Current rare-variant, gene-based tests of association often suffer from a lack of statistical power to detect genotype–phenotype associations as a result of a lack of prior knowledge of genetic disease models combined with limited observations of extremely rare causal variants in population-based sa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133502/ https://www.ncbi.nlm.nih.gov/pubmed/27980630 http://dx.doi.org/10.1186/s12919-016-0024-y |