Interference with Protease-activated Receptor 1 Alleviates Neuronal Cell Death Induced by Lipopolysaccharide-Stimulated Microglial Cells through the PI3K/Akt Pathway

Excessive microglial cells activation in response to inflammatory stimuli leads to synaptic loss, dysfunction, and neuronal cell death. Activated microglia are involved in the pathogenesis of neurological conditions and frequently contribute to several complications. Accumulating evidence suggests t...

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Detalles Bibliográficos
Autores principales: Li, Yuxin, Yang, Wuyang, Quinones-Hinojosa, Alfredo, Wang, Baocheng, Xu, Shujun, Zhu, Weijie, Yu, Feng, Yuan, Shaoji, Lu, Peigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133627/
https://www.ncbi.nlm.nih.gov/pubmed/27910893
http://dx.doi.org/10.1038/srep38247

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